Rabbit Anti-KRT20 Recombinant Antibody (K1843) (V2LY-0826-LY42)

Name: Rabbit Anti-KRT20 Recombinant Antibody (K1843)
SKU: V2LY-0826-LY42
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

K1843

Application

WB, IHC-P

Immunogen

Recombinant fragment of human Cytokeratin 20.

Host Species

Rabbit

Specificity

Human, Mouse

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

Application	Note
WB	1:500-1:3,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

1 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Keratin 20

Entrez Gene ID

Human	54474
Mouse	66809

UniProt ID

Human	P35900
Mouse	Q9D312

Function

Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity).

Biological Process

Apoptotic processIEA:UniProtKB-KW
Cellular response to starvationIEA:Ensembl
Intermediate filament organizationManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of protein secretionIEA:Ensembl

Cellular Location

Cytoplasm

PTM

Hyperphosphorylation at Ser-13 ^oCcurs during the early stages of apoptosis but becomes less prominent during the later stages. Phosphorylation at Ser-13 also increases in response to stress brought on by cell injury (By similarity).
Proteolytically cleaved by caspases during apoptosis. Cleavage occurs at Asp-228.

Lupsa, N., Szegedi, Á., Gézsi, A., Vuncs, Z., Masszi, T., Mikala, G., ... & Pós, Z. (2022). Decreased plasma level of cytokeratin 20 (KRT20) is indicative of the emergence and severity of acute GvHD irrespective to the type of organ involvement. Biomedicines, 10(3), 519.

Jütte, H., Reike, M., Wirtz, R. M., Kriegmair, M., Erben, P., Tully, K., ... & Roghmann, F. (2021). Krt20, krt5, esr1 and erbb2 expression can predict pathologic outcome in patients undergoing neoadjuvant chemotherapy and radical cystectomy for muscle-invasive bladder cancer. Journal of personalized medicine, 11(6), 473.

Hung, C. S., Wang, Y. C., Guo, J. W., Yang, R. N., Lee, C. L., Shen, M. H., ... & Liu, C. Y. (2020). Expression pattern of placenta specific 8 and keratin 20 in different types of gastrointestinal cancer. Molecular Medicine Reports, 21(2), 659-666.

Eckstein, M., Wirtz, R. M., Gross-Weege, M., Breyer, J., Otto, W., Stoehr, R., ... & Erben, P. (2018). mRNA-expression of KRT5 and KRT20 defines distinct prognostic subgroups of muscle-invasive urothelial bladder cancer correlating with histological variants. International journal of molecular sciences, 19(11), 3396.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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