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Rabbit Anti-KRT25 Recombinant Antibody (E19-l) (CBMAB-K1869-LY)

This product is antibody recognizes KRT25. The antibody E19-l immunoassay techniques such as: IHC-P, IHC-Fr.
See all KRT25 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
E19-l
Antibody Isotype
IgG
Application
IHC-P, IHC-Fr

Basic Information

Immunogen
Peptide derived from C-terminal region of human cytokeratin 20
Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Keratin 25
Introduction
This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2009]
Entrez Gene ID
147183
UniProt ID
Q7Z3Z0
Alternative Names
Keratin 25; Type I Inner Root Sheath-Specific Keratin-K25irs1; Keratin 25; Type I; Cytokeratin-25; Keratin-25A; KRT25A; CK-25; K25A;
Function
Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity).
Plays a role in the cytoskeleton organization (PubMed:26902920).
Biological Process
AgingManual Assertion Based On ExperimentIDA:UniProtKB
Cytoskeleton organizationManual Assertion Based On ExperimentIDA:UniProtKB
Hair cycleManual Assertion Based On ExperimentIDA:UniProtKB
Hair follicle morphogenesisIEA:Ensembl
Intermediate filament organizationIEA:Ensembl
Cellular Location
Cytoplasm
Involvement in disease
Woolly hair autosomal recessive 3 (ARWH3):
A hair shaft disorder characterized by fine and tightly curled hair. Compared to normal curly hair that is observed in some populations, woolly hair grows slowly and stops growing after a few inches. Under light microscopy, woolly hair shows some structural anomalies, including trichorrhexis nodosa and tapered ends. Some individuals may present with hypotrichosis.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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