Rabbit Anti-KRT25 Recombinant Antibody (E19-l) (CBMAB-K1869-LY)

Name: Rabbit Anti-KRT25 Recombinant Antibody (E19-l)
SKU: CBMAB-K1869-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

E19-l

Application

IHC-P, IHC-Fr

Immunogen

Peptide derived from C-terminal region of human cytokeratin 20

Specificity

Human

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Keratin 25

Introduction

This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2009]

Entrez Gene ID

147183

UniProt ID

Q7Z3Z0

Alternative Names

Keratin 25; Type I Inner Root Sheath-Specific Keratin-K25irs1; Keratin 25; Type I; Cytokeratin-25; Keratin-25A; KRT25A; CK-25; K25A;

Function

Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity).
Plays a role in the cytoskeleton organization (PubMed:26902920).

Biological Process

AgingManual Assertion Based On ExperimentIDA:UniProtKB
Cytoskeleton organizationManual Assertion Based On ExperimentIDA:UniProtKB
Hair cycleManual Assertion Based On ExperimentIDA:UniProtKB
Hair follicle morphogenesisIEA:Ensembl
Intermediate filament organizationIEA:Ensembl

Cellular Location

Cytoplasm

Involvement in disease

Woolly hair autosomal recessive 3 (ARWH3):
A hair shaft disorder characterized by fine and tightly curled hair. Compared to normal curly hair that is observed in some populations, woolly hair grows slowly and stops growing after a few inches. Under light microscopy, woolly hair shows some structural anomalies, including trichorrhexis nodosa and tapered ends. Some individuals may present with hypotrichosis.

Bao, Q., Zhang, X., Bao, P., Liang, C., Guo, X., Yin, M., ... & Yan, P. (2022). Genome-wide identification, characterization, and expression analysis of keratin genes (KRTs) family in yak (Bos grunniens). Gene, 818, 146247.

Akiyama, M. (2021). Isolated autosomal recessive woolly hair/hypotrichosis: genetics, pathogenesis and therapies. Journal of the European Academy of Dermatology and Venereology, 35(9), 1788-1796.

Ehrlich, F., Laggner, M., Langbein, L., Burger, P., Pollreisz, A., Tschachler, E., & Eckhart, L. (2019). Comparative genomics suggests loss of keratin K24 in three evolutionary lineages of mammals. Scientific reports, 9(1), 10924.

Thomer, A., Gottschalk, M., Christmann, A., Naccache, F., Jung, K., Hewicker-Trautwein, M., ... & Metzger, J. (2018). An epistatic effect of KRT25 on SP6 is involved in curly coat in horses. Scientific reports, 8(1), 6374.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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