Mouse Anti-KRT6A Recombinant Antibody (KRT6/1702) (CBMAB-K1936-LY)

Name: Mouse Anti-KRT6A Recombinant Antibody (KRT6/1702)
SKU: CBMAB-K1936-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

KRT6/1702

Application

IHC-P, IF/ICC, FC

Immunogen

Recombinant human full-length keratin 6 protein

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

0.05% BSA

Preservative

0.05% sodium azide

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Keratin 6A

Introduction

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. In addition, peptides from the C-terminal region of the protein have antimicrobial activity against bacterial pathogens. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Oct 2014]

Entrez Gene ID

3853

UniProt ID

P02538

Alternative Names

Keratin 6A; Keratin 6A; Type II; Type-II Keratin Kb6; KRT6D; K6A; Keratin; Type II Cytoskeletal 6A; Keratin; Type II Cytoskeletal 6C; Keratin; Epidermal Type II; K6A; Keratin 6A; ; Type II; Allergen Hom S 5; Cytokeratin 6A; Cytokeratin 6C; Cytokeratin 6D; Cytokeratin-6A; Cytokeratin-6D;

Function

Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair.

Biological Process

Antimicrobial humoral immune response mediated by antimicrobial peptideManual Assertion Based On ExperimentIDA:UniProtKB
Cell differentiation1 PublicationNAS:UniProtKB
Cytolysis by host of symbiont cellsManual Assertion Based On ExperimentIDA:UniProtKB
Defense response to Gram-positive bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Norphogenesis of an epitheliumISS:UniProtKB
Negative regulation of cytolysis by symbiont of host cellsManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of entry of bacterium into host cellManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cell population proliferation1 PublicationNAS:UniProtKB
Wound healingISS:UniProtKB

Cellular Location

Cytosol
Extracellular exosome
Keratin filament
Membrane
Nucleus

Involvement in disease

Pachyonychia congenita 3 (PC3):
An autosomal dominant genodermatosis characterized by hypertrophic nail dystrophy, painful and highly debilitating plantar keratoderma, oral leukokeratosis, and a variety of epidermal cysts.

Zhu, A. Y., Mitra, N., & Margolis, D. J. (2022). Longitudinal association of atopic dermatitis progression and keratin 6A. Scientific Reports, 12(1), 13629.

Yoshida, A., Yamamoto, K., Ishida, T., Omura, T., Itoh, T., Nishigori, C., ... & Yano, I. (2021). Sunitinib decreases the expression of KRT6A and SERPINB1 in 3D human epidermal models. Experimental dermatology, 30(3), 337-346.

Che, D., Wang, M., Sun, J., Li, B., Xu, T., Lu, Y., ... & Gu, X. (2021). KRT6A promotes lung cancer cell growth and invasion through MYC-regulated pentose phosphate pathway. Frontiers in Cell and Developmental Biology, 9, 694071.

Yang, B., Zhang, W., Zhang, M., Wang, X., Peng, S., & Zhang, R. (2020). KRT6A promotes EMT and cancer stem cell transformation in lung adenocarcinoma. Technology in cancer research & treatment, 19, 1533033820921248.

Xiao, J., Kuang, X., Dai, L., Zhang, L., & He, B. (2020). Anti‐tumour effects of Keratin 6A in lung adenocarcinoma. The Clinical Respiratory Journal, 14(7), 667-674.

Chen, C., & Shan, H. (2019). Keratin 6A gene silencing suppresses cell invasion and metastasis of nasopharyngeal carcinoma via the β‑catenin cascade. Molecular Medicine Reports, 19(5), 3477-3484.

Wang, F., Chen, S., Liu, H. B., Parent, C. A., & Coulombe, P. A. (2018). Keratin 6 regulates collective keratinocyte migration by altering cell–cell and cell–matrix adhesion. Journal of Cell Biology, 217(12), 4314-4330.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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