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Mouse Anti-KRT6A Recombinant Antibody (CBWJC-4071) (CBMAB-C5402WJ)

This product is a Mouse antibody that recognizes KRT6A. This antibody CBWJC-4071 can be used for immunoassay techniques such as: FC, IF, WB, IHC-P.
See all KRT6A antibodies

Summary

Host Animal
Mouse
Specificity
Human, Monkey, Cattle, Pig, Goat, Rat, Mouse, Guinea Pig, Frog
Clone
CBWJC-4071
Antibody Isotype
IgG1
Application
FC, IF, WB, IHC-P

Basic Information

Specificity
Human, Monkey, Cattle, Pig, Goat, Rat, Mouse, Guinea Pig, Frog
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
10mM PBS, 0.05% BSA
Concentration
0.2 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Keratin 6A
Introduction
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. In addition, peptides from the C-terminal region of the protein have antimicrobial activity against bacterial pathogens. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Oct 2014]
Entrez Gene ID
Human3853
Mouse16687
Rat120093743
Pig102164968
Cattle614456
Goat102174931
Guinea pig100715629
UniProt ID
HumanP02538
MouseP50446
RatQ4FZU2
CattleM0QVY0
Alternative Names
Keratin 6A; Keratin 6A, Type II; Type-II Keratin Kb6; KRT6D; K6A; Keratin, Type II Cytoskeletal 6A; Keratin, Type II Cytoskeletal 6C; Keratin, Epidermal Type II, K6A; Keratin 6A, Type II; Allergen Hom S 5; Cytokeratin 6A; Cytokeratin 6C; Cytokeratin 6D; Cytokeratin-6A; Cytokeratin-6D;
Function
Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair.
Biological Process
Antimicrobial humoral immune response mediated by antimicrobial peptideManual Assertion Based On ExperimentIDA:UniProtKB
Cell differentiation1 PublicationNAS:UniProtKB
Cytolysis by host of symbiont cellsManual Assertion Based On ExperimentIDA:UniProtKB
Defense response to Gram-positive bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Norphogenesis of an epitheliumISS:UniProtKB
Negative regulation of cytolysis by symbiont of host cellsManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of entry of bacterium into host cellManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cell population proliferation1 PublicationNAS:UniProtKB
Wound healingISS:UniProtKB
Cellular Location
Cytosol
Extracellular exosome
Keratin filament
Membrane
Nucleus
Involvement in disease
Pachyonychia congenita 3 (PC3):
An autosomal dominant genodermatosis characterized by hypertrophic nail dystrophy, painful and highly debilitating plantar keratoderma, oral leukokeratosis, and a variety of epidermal cysts.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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