Sign in or Register   Sign in or Register
  |  

Rabbit Anti-KRT6A Recombinant Antibody (CBLY1-155) (CBMAB-K1935-LY)

This product is antibody recognizes KRT6A. The antibody CBLY1-155 immunoassay techniques such as: WB, ICC, IHC-P.
See all KRT6A antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBLY1-155
Antibody Isotype
IgG
Application
WB, ICC, IHC-P

Basic Information

Immunogen
A synthetic peptide corresponding to residues on the C-terminus of human CK-6A was used as an immunogen
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Keratin 6A
Introduction
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. In addition, peptides from the C-terminal region of the protein have antimicrobial activity against bacterial pathogens. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Oct 2014]
Entrez Gene ID
UniProt ID
Alternative Names
Keratin 6A; Keratin 6A; Type II; Type-II Keratin Kb6; KRT6D; K6A; Keratin; Type II Cytoskeletal 6A; Keratin; Type II Cytoskeletal 6C; Keratin; Epidermal Type II; K6A; Keratin 6A; ; Type II; Allergen Hom S 5; Cytokeratin 6A; Cytokeratin 6C; Cytokeratin 6D; Cytokeratin-6A; Cytokeratin-6D;
Function
Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair.
Biological Process
Antimicrobial humoral immune response mediated by antimicrobial peptideManual Assertion Based On ExperimentIDA:UniProtKB
Cell differentiation1 PublicationNAS:UniProtKB
Cytolysis by host of symbiont cellsManual Assertion Based On ExperimentIDA:UniProtKB
Defense response to Gram-positive bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Norphogenesis of an epitheliumISS:UniProtKB
Negative regulation of cytolysis by symbiont of host cellsManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of entry of bacterium into host cellManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cell population proliferation1 PublicationNAS:UniProtKB
Wound healingISS:UniProtKB
Cellular Location
Cytosol
Extracellular exosome
Keratin filament
Membrane
Nucleus
Involvement in disease
Pachyonychia congenita 3 (PC3):
An autosomal dominant genodermatosis characterized by hypertrophic nail dystrophy, painful and highly debilitating plantar keratoderma, oral leukokeratosis, and a variety of epidermal cysts.
Ask a question We look forward to hearing from you.
0 reviews or Q&As
Loading...
Have you used Rabbit Anti-KRT6A Recombinant Antibody (CBLY1-155)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare