Mouse Anti-KRT6A Recombinant Antibody (CBT3396) (V2LY-0625-LY1524)

Name: Mouse Anti-KRT6A Recombinant Antibody (CBT3396)
SKU: V2LY-0625-LY1524
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-KRT6A Recombinant Antibody (CBT3396) (V2LY-0625-LY1524) in ELISA

Mouse Anti-KRT6A Recombinant Antibody (CBT3396) (V2LY-0625-LY1524) in WB

Mouse Anti-KRT6A Recombinant Antibody (CBT3396) (V2LY-0625-LY1524) in FC

Mouse Anti-KRT6A Recombinant Antibody (CBT3396) (V2LY-0625-LY1524) in IF

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBT3396

Application

WB, ICC, FC

Immunogen

Purified recombinant fragment of human KRT6A (AA: 253-352) expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
ICC	1:200-1:1,000
FC	1:200-1:400
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Keratin 6A

Entrez Gene ID

3853

UniProt ID

P02538

Function

Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair.

Biological Process

Antimicrobial humoral immune response mediated by antimicrobial peptideManual Assertion Based On ExperimentIDA:UniProtKB
Cell differentiation1 PublicationNAS:UniProtKB
Cytolysis by host of symbiont cellsManual Assertion Based On ExperimentIDA:UniProtKB
Defense response to Gram-positive bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Norphogenesis of an epitheliumISS:UniProtKB
Negative regulation of cytolysis by symbiont of host cellsManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of entry of bacterium into host cellManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cell population proliferation1 PublicationNAS:UniProtKB
Wound healingISS:UniProtKB

Cellular Location

Cytosol
Extracellular exosome
Keratin filament
Membrane
Nucleus

Involvement in disease

Pachyonychia congenita 3 (PC3):
An autosomal dominant genodermatosis characterized by hypertrophic nail dystrophy, painful and highly debilitating plantar keratoderma, oral leukokeratosis, and a variety of epidermal cysts.

Zhu, A. Y., Mitra, N., & Margolis, D. J. (2022). Longitudinal association of atopic dermatitis progression and keratin 6A. Scientific Reports, 12(1), 13629.

Yoshida, A., Yamamoto, K., Ishida, T., Omura, T., Itoh, T., Nishigori, C., ... & Yano, I. (2021). Sunitinib decreases the expression of KRT6A and SERPINB1 in 3D human epidermal models. Experimental dermatology, 30(3), 337-346.

Che, D., Wang, M., Sun, J., Li, B., Xu, T., Lu, Y., ... & Gu, X. (2021). KRT6A promotes lung cancer cell growth and invasion through MYC-regulated pentose phosphate pathway. Frontiers in Cell and Developmental Biology, 9, 694071.

Yang, B., Zhang, W., Zhang, M., Wang, X., Peng, S., & Zhang, R. (2020). KRT6A promotes EMT and cancer stem cell transformation in lung adenocarcinoma. Technology in cancer research & treatment, 19, 1533033820921248.

Xiao, J., Kuang, X., Dai, L., Zhang, L., & He, B. (2020). Anti‐tumour effects of Keratin 6A in lung adenocarcinoma. The Clinical Respiratory Journal, 14(7), 667-674.

Chen, C., & Shan, H. (2019). Keratin 6A gene silencing suppresses cell invasion and metastasis of nasopharyngeal carcinoma via the β‑catenin cascade. Molecular Medicine Reports, 19(5), 3477-3484.

Wang, F., Chen, S., Liu, H. B., Parent, C. A., & Coulombe, P. A. (2018). Keratin 6 regulates collective keratinocyte migration by altering cell–cell and cell–matrix adhesion. Journal of Cell Biology, 217(12), 4314-4330.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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