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Mouse Anti-KRT6B Recombinant Antibody (3B6) (CBMAB-K1937-LY)

This product is antibody recognizes KRT6B. The antibody 3B6 immunoassay techniques such as: ELISA, WB.
See all KRT6B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3B6
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
KRT6B (AAH34535, 1 a.a. ~ 564 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
keratin 6B
Introduction
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
Entrez Gene ID
3854
UniProt ID
P04259
Alternative Names
Keratin 6B; Keratin-Like 1 (A Type II Keratin Sequence); Type-II Keratin Kb10; Keratin 6B; Type II; KRTL1; CK-6B; K6B; Keratin; Epidermal; Type II; K6B;
Biological Process
Ectoderm developmentManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytosol
Extracellular exosome
Keratin filament
Involvement in disease
Pachyonychia congenita 4 (PC4):
An autosomal dominant genodermatosis characterized by hypertrophic nail dystrophy, painful and highly debilitating plantar keratoderma, oral leukokeratosis, and a variety of epidermal cysts.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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