Mouse Anti-KRT6B Recombinant Antibody (3B6) (CBMAB-K1937-LY)

Name: Mouse Anti-KRT6B Recombinant Antibody (3B6)
SKU: CBMAB-K1937-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

3B6

Application

ELISA, WB

Immunogen

KRT6B (AAH34535, 1 a.a. ~ 564 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

keratin 6B

Introduction

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]

Entrez Gene ID

3854

UniProt ID

P04259

Alternative Names

Keratin 6B; Keratin-Like 1 (A Type II Keratin Sequence); Type-II Keratin Kb10; Keratin 6B; Type II; KRTL1; CK-6B; K6B; Keratin; Epidermal; Type II; K6B;

Biological Process

Ectoderm developmentManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cytosol
Extracellular exosome
Keratin filament

Involvement in disease

Pachyonychia congenita 4 (PC4):
An autosomal dominant genodermatosis characterized by hypertrophic nail dystrophy, painful and highly debilitating plantar keratoderma, oral leukokeratosis, and a variety of epidermal cysts.

Liu, L., Yang, Y., Shang, A., Liu, C., Sun, C., & Wang, J. (2022). Expression and regulation of keratin 6B in CD44+ bladder cancer stem cells. Chinese Journal of Tissue Engineering Research, 26(1), 76.

Mathews, J., Hansen, C. D., & Chandrashekar, L. (2021). Homozygous dominant missense mutation in Keratin 6b leading to severe pachyonychia congenita. Clinical & Experimental Dermatology, 46(2).

Zhang, X., Yin, M., & Zhang, L. J. (2019). Keratin 6, 16 and 17—critical barrier alarmin molecules in skin wounds and psoriasis. Cells, 8(8), 807.

Wang, F., Chen, S., Liu, H. B., Parent, C. A., & Coulombe, P. A. (2018). Keratin 6 regulates collective keratinocyte migration by altering cell–cell and cell–matrix adhesion. Journal of Cell Biology, 217(12), 4314-4330.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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