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Mouse Anti-KRT8 Recombinant Antibody (CBXC-1920) (CBMAB-C4015-CQ)

This product is a mouse antibody that recognizes KRT8. The antibody CBXC-1920 can be used for immunoassay techniques such as: WB, IHC, IF, IHC-P.
See all KRT8 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-1920
Antibody Isotype
IgG2b
Application
WB, IHC, IF, IHC-P

Basic Information

Immunogen
Recombinant fragment expressed in E. coli corresponding to amino acids 91-381 of human CK8
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Keratin 8
Introduction
This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene.
Entrez Gene ID
UniProt ID
Alternative Names
Keratin 8; Type-II Keratin Kb8; Keratin 8, Type II; Cytokeratin-8; CK-8; CYK8; K8;
Function
Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
Cellular Location
Cytoplasm 2 Publications
Nucleus, nucleoplasm By Similarity
Nucleus matrix
Involvement in disease
Cirrhosis (CIRRH):
A liver disease characterized by severe panlobular liver-cell swelling with Mallory body formation, prominent pericellular fibrosis, and marked deposits of copper. Clinical features include abdomen swelling, jaundice and pulmonary hypertension.
PTM
Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization.
O-glycosylated. O-GlcNAcylation at multiple sites increases solubility, and decreases stability by inducing proteasomal degradation.
O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.

Wang, D., Shang, Q., Mao, J., Gao, C., Wang, J., Wang, D., ... & Yang, L. (2023). Phosphorylation of KRT8 (keratin 8) by excessive mechanical load-activated PKN (protein kinase N) impairs autophagosome initiation and contributes to disc degeneration. Autophagy, 1-19.

Xiong, F., Guo, T., Wang, X., Wu, G., Liu, W., Wang, Q., ... & Chen, Y. (2022). Keratin 8 Is an Inflammation-Induced and Prognosis-Related Marker for Pancreatic Adenocarcinoma. Disease Markers, 2022.

Son, S., Baek, A., Lee, J. H., & Kim, D. E. (2022). Autophagosome–lysosome fusion is facilitated by plectin-stabilized actin and keratin 8 during macroautophagic process. Cellular and Molecular Life Sciences, 79(2), 95.

Baek, A., Son, S., Baek, Y. M., & Kim, D. E. (2021). KRT8 (keratin 8) attenuates necrotic cell death by facilitating mitochondrial fission-mediated mitophagy through interaction with PLEC (plectin). Autophagy, 17(12), 3939-3956.

Albaret, M. A., Paré, A., Malet, L., De Souza, G., Lavergne, E., Goga, D., ... & Saintigny, P. (2021). Combined proteomic and transcriptomic approaches reveal externalized keratin 8 as a potential therapeutic target involved in invasiveness of head and neck cancers. Translational Oncology, 14(1), 100878.

Miao, Q., Xu, Y., Yin, H., Zhang, H., & Ye, J. (2020). KRT8 phosphorylation regulates the epithelial‐mesenchymal transition in retinal pigment epithelial cells through autophagy modulation. Journal of Cellular and Molecular Medicine, 24(5), 3217-3228.

Golob-Schwarzl, N., Bettermann, K., Mehta, A. K., Kessler, S. M., Unterluggauer, J., Krassnig, S., ... & Haybaeck, J. (2019). High keratin 8/18 ratio predicts aggressive hepatocellular cancer phenotype. Translational oncology, 12(2), 256-268.

Xie, L., Dang, Y., Guo, J., Sun, X., Xie, T., Zhang, L., ... & Guo, X. (2019). High KRT8 expression independently predicts poor prognosis for lung adenocarcinoma patients. Genes, 10(1), 36.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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