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Rabbit Anti-KTN1 Recombinant Antibody (D5F7J) (CBMAB-K2081-LY)

This product is antibody recognizes KTN1. The antibody D5F7J immunoassay techniques such as: WB, IP, IF.
See all KTN1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Monkey, Dog
Clone
D5F7J
Antibody Isotype
IgG
Application
WB, IP, IF

Basic Information

Specificity
Human, Monkey, Dog
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Kinectin 1
Introduction
This gene encodes an integral membrane protein that is a member of the kinectin protein family. The encoded protein is primarily localized to the endoplasmic reticulum membrane. This protein binds kinesin and may be involved in intracellular organelle motility. This protein also binds translation elongation factor-delta and may be involved in the assembly of the elongation factor-1 complex. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Aug 2012]
Entrez Gene ID
Human3895
Monkey697744
Dog480332
UniProt ID
HumanQ86UP2
MonkeyA0A0D9RQ20
DogE2RG59
Function
Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin.
Biological Process
Microtubule-based movement1 PublicationNAS:ProtInc
Protein transportIEA:InterPro
Cellular Location
Endoplasmic reticulum membrane
Vesicle membrane protein anchored to the endoplasmic reticulum.
Topology
Cytoplasmic: 1-6
Helical: 7-29
Lumenal: 30-1357

Gao, L., Zhou, W., Xie, N., Qiu, J., Huang, J., Zhang, Z., ... & Zou, C. (2022). Yin Yang 1 promotes aggressive cell growth in high‐grade breast cancer by directly transactivating kinectin 1. MedComm, 3(3), e133.

Chen, L., Lu, J., Xu, T., Yan, Z., Guo, Y., Dong, Z., & Guo, W. (2022). KTN1-AS1, a SOX2-mediated lncRNA, activates epithelial–mesenchymal transition process in esophageal squamous cell carcinoma. Scientific Reports, 12(1), 20186.

Gao, L., Chen, S., Hong, M., Zhou, W., Wang, B., Qiu, J., ... & Zou, C. (2021). Kinectin 1 promotes the growth of triple-negative breast cancer via directly co-activating NF-kappaB/p65 and enhancing its transcriptional activity. Signal Transduction and Targeted Therapy, 6(1), 250.

Jakob, M., Mattes, L. M., Unger, K., Kueffer, S., Hess, J., Canis, M., ... & Kitz, J. (2021). Human microRNA‐182‐5p and kinectin 1: Potential biomarkers for prognosis in oral squamous cell carcinoma. Head & Neck, 43(12), 3707-3719.

Pan, J., Chao, N. X., Zhang, Y. Y., Huang, T. M., Chen, C. X., Qin, Q. H., ... & Luo, G. R. (2021). Upregulating KTN1 promotes Hepatocellular Carcinoma progression. Journal of Cancer, 12(16), 4791.

Luo, X., Guo, X., Luo, X., Tan, Y., Zhang, P., Yang, K., ... & Li, C. S. R. (2021). Significant, replicable, and functional associations between KTN1 variants and alcohol and drug codependence. Addiction biology, 26(2), e12888.

Mu, Y., Tang, Q., Feng, H., Zhu, L., & Wang, Y. (2020). lncRNA KTN1‑AS1 promotes glioma cell proliferation and invasion by negatively regulating miR‑505‑3p. Oncology reports, 44(6), 2645-2655.

Luo, X., Guo, X., Tan, Y., Zhang, Y., Garcia‐Milian, R., Wang, Z., ... & Li, C. S. R. (2020). KTN1 variants and risk for attention deficit hyperactivity disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 183(4), 234-244.

Zhang, Y., Gao, L., Ma, S., Ma, J., Wang, Y., Li, S., ... & Ding, Z. (2019). MALAT1-KTN1-EGFR regulatory axis promotes the development of cutaneous squamous cell carcinoma. Cell Death & Differentiation, 26(10), 2061-2073.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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