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Rabbit Anti-L1CAM Recombinant Antibody (001) (CBMAB-C1472-LY)

This product is antibody recognizes L1CAM. The antibody 001 immunoassay techniques such as: ELISA(Cap).
See all L1CAM antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
001
Antibody Isotype
IgG
Application
ELISA(Cap)

Basic Information

Immunogen
Recombinant Human CD171 / L1CAM Protein
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
L1CAM
Entrez Gene ID
UniProt ID
Function
Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity.
Biological Process
Axon developmentManual Assertion Based On ExperimentIDA:UniProtKB
Axon guidanceManual Assertion Based On ExperimentIDA:UniProtKB
Cell adhesion1 PublicationNAS:ProtInc
Cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Cell-matrix adhesionManual Assertion Based On ExperimentIDA:UniProtKB
ChemotaxisManual Assertion Based On ExperimentTAS:BHF-UCL
Homophilic cell adhesion via plasma membrane adhesion moleculesManual Assertion Based On ExperimentIBA:GO_Central
Nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Neuron projection developmentManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of axon extensionISS:UniProtKB
Synapse organizationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cell membrane
Cell projection, growth cone
Cell projection, axon
Cell projection, dendrite
Colocalized with SHTN1 in close apposition with actin filaments in filopodia and lamellipodia of axonalne growth cones of hippocampal neurons (By similarity).
In neurons, detected predominantly in axons and cell body, weak localization to dendrites (PubMed:20621658).
Involvement in disease
Hydrocephalus due to stenosis of the aqueduct of Sylvius (HSAS):
Hydrocephalus is a condition in which abnormal accumulation of cerebrospinal fluid in the brain causes increased intracranial pressure inside the skull. This is usually due to blockage of cerebrospinal fluid outflow in the brain ventricles or in the subarachnoid space at the base of the brain. In children is typically characterized by enlargement of the head, prominence of the forehead, brain atrophy, mental deterioration, and convulsions. In adults the syndrome includes incontinence, imbalance, and dementia. HSAS is characterized by mental retardation and enlarged brain ventricles.
Mental retardation, aphasia, shuffling gait, and adducted thumbs syndrome (MASA):
An X-linked recessive syndrome with a highly variable clinical spectrum. Main clinical features include spasticity and hyperreflexia of lower limbs, shuffling gait, mental retardation, aphasia and adducted thumbs. The features of spasticity have been referred to as complicated spastic paraplegia type 1 (SPG1). Some patients manifest corpus callosum hypoplasia and hydrocephalus. Inter- and intrafamilial variability is very wide, such that patients with hydrocephalus, MASA, SPG1, and agenesis of corpus callosum can be present within the same family.
Agenesis of the corpus callosum, X-linked, partial (ACCPX):
A syndrome characterized by partial corpus callosum agenesis, hypoplasia of inferior vermis and cerebellum, mental retardation, seizures and spasticity. Other features include microcephaly, unusual facies, and Hirschsprung disease in some patients.
Defects in L1CAM are associated with a wide phenotypic spectrum which varies from severe hydrocephalus and prenatal death (HSAS) to a milder phenotype (MASA). These variations may even occur within the same family. Due to the overlap of phenotypes between HSAS and MASA, many authors use the general concept of L1 syndrome which covers both ends of the spectrum.
Topology
Extracellular: 20-1120
Helical: 1121-1143
Cytoplasmic: 1144-1257

Gomes, D. E., & Witwer, K. W. (2022). L1CAM‐associated extracellular vesicles: A systematic review of nomenclature, sources, separation, and characterization. Journal of extracellular biology, 1(3), e35.

Norman, M., Ter-Ovanesyan, D., Trieu, W., Lazarovits, R., Kowal, E. J., Lee, J. H., ... & Walt, D. R. (2021). L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma. Nature Methods, 18(6), 631-634.

Giordano, M., Decio, A., Battistini, C., Baronio, M., Bianchi, F., Villa, A., ... & Cavallaro, U. (2021). L1CAM promotes ovarian cancer stemness and tumor initiation via FGFR1/SRC/STAT3 signaling. Journal of Experimental & Clinical Cancer Research, 40(1), 1-19.

Altevogt, P., Ben‐Ze'ev, A., Gavert, N., Schumacher, U., Schäfer, H., & Sebens, S. (2020). Recent insights into the role of L1CAM in cancer initiation and progression. International Journal of Cancer, 147(12), 3292-3296.

Giordano, M., & Cavallaro, U. (2020). Different shades of L1CAM in the pathophysiology of cancer stem cells. Journal of Clinical Medicine, 9(5), 1502.

Ganesh, K., Basnet, H., Kaygusuz, Y., Laughney, A. M., He, L., Sharma, R., ... & Massagué, J. (2020). L1CAM defines the regenerative origin of metastasis-initiating cells in colorectal cancer. Nature cancer, 1(1), 28-45.

Linneberg, C., Toft, C. L. F., Kjaer-Sorensen, K., & Laursen, L. S. (2019). L1cam-mediated developmental processes of the nervous system are differentially regulated by proteolytic processing. Scientific reports, 9(1), 3716.

Corrado, G., Laquintana, V., Loria, R., Carosi, M., de Salvo, L., Sperduti, I., ... & Vizza, E. (2018). Endometrial cancer prognosis correlates with the expression of L1CAM and miR34a biomarkers. Journal of Experimental & Clinical Cancer Research, 37, 1-10.

Kommoss, F. K., Karnezis, A. N., Kommoss, F., Talhouk, A., Taran, F. A., Staebler, A., ... & Kommoss, S. (2018). L1CAM further stratifies endometrial carcinoma patients with no specific molecular risk profile. British journal of cancer, 119(4), 480-486.

Wachowiak, R., Krause, M., Mayer, S., Peukert, N., Suttkus, A., Müller, W. C., ... & Nestler, U. (2018). Increased L1CAM (CD171) levels are associated with glioblastoma and metastatic brain tumors. Medicine, 97(38).

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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