Rabbit Anti-L1RE1 Recombinant Antibody (CBYJL-1031) (CBMAB-L0443-YJ)

Name: Rabbit Anti-L1RE1 Recombinant Antibody (CBYJL-1031)
SKU: CBMAB-L0443-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBYJL-1031

Application

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Line-1 Retrotransposable Element Orf1 Protein

Introduction

Nucleic acid-binding protein which is necessary for retrotransposition of LINE-1 elements in the genome. L1RE1 functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded.

UniProt ID

Q9UN81

Alternative Names

L1RE1; LRE1

Function

Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded.

Biological Process

Transposition, RNA-mediatedManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Nucleus, nucleolus
Cytoplasm, Cytoplasmic ribonucleoprotein granule
Cytoplasm, Stress granule
Colocalizes with its encoding RNA in cytoplasmic ribonucleoprotein particle (PubMed:16183655).
Mainly cytoplasmic, rarely detected in the nucleus, possibly within the nucleolus (PubMed:17562864).

PTM

Polyubiquitinated, probably by UBR2, which induces its degradation.

Walter, R. F. H., Rozynek, P., Casjens, S., Werner, R., Mairinger, F. D., Speel, E. J. M., ... & Johnen, G. (2018). Methylation of L1RE1, RARB, and RASSF1 function as possible biomarkers for the differential diagnosis of lung cancer. PloS one, 13(5), e0195716.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Rabbit Anti-L1RE1 Recombinant Antibody (D3W9O) (CAT#: CBMAB-CP1327-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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