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L1RE1

Nucleic acid-binding protein which is necessary for retrotransposition of LINE-1 elements in the genome. L1RE1 functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded.

Full Name

Line-1 Retrotransposable Element Orf1 Protein

Function

Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded.

Biological Process

Transposition, RNA-mediatedManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Nucleus, nucleolus
Cytoplasm, Cytoplasmic ribonucleoprotein granule
Cytoplasm, Stress granule
Colocalizes with its encoding RNA in cytoplasmic ribonucleoprotein particle (PubMed:16183655).
Mainly cytoplasmic, rarely detected in the nucleus, possibly within the nucleolus (PubMed:17562864).

PTM

Polyubiquitinated, probably by UBR2, which induces its degradation.

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Anti-L1RE1 antibodies

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Rabbit Anti-L1RE1 Recombinant Antibody (CBYJL-1031) (CBMAB-L0443-YJ)

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Target: L1RE1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJL-1031

Application*: WB

Rabbit Anti-L1RE1 Recombinant Antibody (D3W9O) (CBMAB-CP1327-LY)

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Target: L1RE1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: D3W9O

Application*: WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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