Sign in or Register   Sign in or Register
  |  

Mouse Anti-L3MBTL2 Recombinant Antibody (4F4) (CBMAB-A4844-LY)

The product is antibody recognizes L3MBTL2. The antibody 4F4 immunoassay techniques such as: WB, ELISA.
See all L3MBTL2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4F4
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
L3MBTL2 (NP_113676, 642 a.a. ~ 705 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
l(3)mbt-like 2 (Drosophila)
Entrez Gene ID
83746
UniProt ID
Q969R5
Alternative Names
H-l(3)mbt-l; L3MBT
Function
Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'.
Biological Process
Chromatin organizationIEA:UniProtKB-KW
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus

Zhong, L., Wang, J., Chen, W., Lv, D., Zhang, R., Wang, X., ... & Liao, D. (2023). Augmenting L3MBTL2-induced condensates suppresses tumor growth in osteosarcoma. Science Advances, 9(47), eadi0889.

Huang, H., Pan, R., Zhao, Y., Li, H., Zhu, H., Wang, S., ... & Liu, X. (2022). L3MBTL2-mediated CGA transcriptional suppression promotes pancreatic cancer progression through modulating autophagy. Iscience, 25(5), 104249.

Liu, J., Li, X., Zhou, G., Sang, Y., Zhang, Y., Zhao, Y., ... & Zhou, X. (2020). Silica nanoparticles induce spermatogenesis disorders via L3MBTL2-DNA damage-p53 apoptosis and RNF8-ubH2A/ubH2B pathway in mice. Environmental Pollution, 265, 114974.

Meng, C., Liao, J., Zhao, D., Huang, H., Qin, J., Lee, T. L., ... & Xia, Y. (2019). L3MBTL2 regulates chromatin remodeling during spermatogenesis. Cell Death & Differentiation, 26(11), 2194-2207.

Stielow, B., Finkernagel, F., Stiewe, T., Nist, A., & Suske, G. (2018). MGA, L3MBTL2 and E2F6 determine genomic binding of the non-canonical Polycomb repressive complex PRC1. 6. PLoS genetics, 14(1), e1007193.

Nowsheen, S., Aziz, K., Aziz, A., Deng, M., Qin, B., Luo, K., ... & Lou, Z. (2018). L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. Nature cell biology, 20(4), 455-464.

Huang, H., Xu, C., Wang, Y., Meng, C., Liu, W., Zhao, Y., ... & Xia, Y. (2018). Lethal (3) malignant brain tumor-like 2 (L3MBTL2) protein protects against kidney injury by inhibiting the DNA damage–p53–apoptosis pathway in renal tubular cells. Kidney International, 93(4), 855-870.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-L3MBTL2 Recombinant Antibody (4F4)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare