L3MBTL2

Related pathways of L3MBTL2 are SUMOylation and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include methylated histone binding and histone binding. An important paralog of this gene is MBTD1. Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated Lys-20 on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on Lys-4, Lys-9 or Lys-27.

Full Name

l(3)mbt-like 2 (Drosophila)

Function

Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'.

Biological Process

Chromatin organizationIEA:UniProtKB-KW
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus