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Mouse Anti-L3MBTL3 Recombinant Antibody (CBYJL-1038) (CBMAB-L0450-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to L3Mbtl3 Histone Methyl-Lysine Binding Protein (L3MBTL3). The antibody can be used for immunoassay techniques, such as IP, WB.
See all L3MBTL3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJL-1038
Antibody Isotype
IgG
Application
IP, WB

Basic Information

Immunogen
229-551 of 780 of L3MBTL3 Protein.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Preservative
0.09% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 229-551

Target

Full Name
L3MBTL3 histone methyl-lysine binding protein
Introduction
L3MBTL3 is a member of the malignant brain tumor (MBT) family of chromatin interacting transcriptional repressors. Members of this family play a role as methyl-lysine readers, which recognize methylated lysine residues on histone protein tails, and are associated with the repression of gene expression. The encoded protein may regulate hematopoiesis. Homozygous deletion of this gene has been observed in human patients with medulloblastoma.
Entrez Gene ID
84456
UniProt ID
Q96JM7
Alternative Names
MBT-1; MBT1
Function
Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Required for normal maturation of myeloid progenitor cells (By similarity).
Biological Process
Chromatin organizationIEA:UniProtKB-KW
Erythrocyte maturationIEA:Ensembl
Granulocyte differentiationIEA:Ensembl
Macrophage differentiationIEA:Ensembl
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIBA:GO_Central
Regulation of DNA methylation-dependent heterochromatin assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus

Wang, M., Wang, D., Lang, Y., Shao, A., Zhang, R., Tang, J., ... & Xiao, C. (2023). L3MBTL3 is induced by HIF-1α and fine tunes the HIF-1α degradation under hypoxia in vitro. Heliyon, 9(2).

Xiao, J., Wang, J., Li, J., Xiao, J., Liu, C., Tan, L., ... & Feng, J. (2023). L3MBTL3 and active STAT3 collaboratively up-regulate SNAIL transcription to promote metastasis in breast cancer.

Hall, D., Giaimo, B. D., Park, S. S., Hemmer, W., Friedrich, T., Ferrante, F., ... & Kovall, R. A. (2022). The structure, binding and function of a Notch transcription complex involving RBPJ and the epigenetic reader protein L3MBTL3. Nucleic Acids Research, 50(22), 13083-13099.

Alcina, A., Fedetz, M., Vidal-Cobo, I., Andrés-León, E., García-Sánchez, M. I., Barroso-del-Jesus, A., ... & Matesanz, F. (2022). Identification of the genetic mechanism that associates L3MBTL3 to multiple sclerosis. Human Molecular Genetics, 31(13), 2155-2163.

Xiong, J., Niu, Y., Liu, W., Zeng, F., Cheng, J. F., Chen, S. Q., & Zeng, X. Z. (2022). Effect of L3MBTL3/PTPN9 polymorphisms on risk to alcohol-induced ONFH in Chinese Han population. Neurological Sciences, 1-8.

Li, Y., Zhang, J., He, J., Chen, X., Zhang, X., Wu, H., & Ding, Y. (2022). Association of the L3MBTL3 rs1125970 and rs4897367 gene polymorphisms with coronary heart disease susceptibility in the Chinese population: a case-control study. Journal of Cardiovascular Pharmacology, 10-1097.

Zhang, C., Leng, F., Saxena, L., Hoang, N., Yu, J., Alejo, S., ... & Zhang, H. (2019). Proteolysis of methylated SOX2 protein is regulated by L3MBTL3 and CRL4DCAF5 ubiquitin ligase. Journal Of Biological Chemistry, 294(2), 476-489.

Nazari Mehrabani, S. Z., Shushizadeh, M. H., Abazari, M. F., Nouri Aleagha, M., Ardalan, A., Abdollahzadeh, R., & Azarnezhad, A. (2019). Association of SHMT1, MAZ, ERG, and L3MBTL3 gene polymorphisms with susceptibility to multiple sclerosis. Biochemical genetics, 57, 355-370.

Leng, F., Yu, J., Zhang, C., Alejo, S., Hoang, N., Sun, H., ... & Zhang, H. (2018). Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4DCAF5 ubiquitin ligase. Nature communications, 9(1), 1641.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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