L3MBTL3

L3MBTL3 is a member of the malignant brain tumor (MBT) family of chromatin interacting transcriptional repressors. Members of this family play a role as methyl-lysine readers, which recognize methylated lysine residues on histone protein tails, and are associated with the repression of gene expression. The encoded protein may regulate hematopoiesis. Homozygous deletion of this gene has been observed in human patients with medulloblastoma.

Full Name

L3MBTL3 histone methyl-lysine binding protein

Function

Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Required for normal maturation of myeloid progenitor cells (By similarity).

Biological Process

Chromatin organizationIEA:UniProtKB-KW
Erythrocyte maturationIEA:Ensembl
Granulocyte differentiationIEA:Ensembl
Macrophage differentiationIEA:Ensembl
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIBA:GO_Central
Regulation of DNA methylation-dependent heterochromatin assemblyManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Nucleus