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Rabbit Anti-Lama2 Recombinant Antibody (CBYJL-2398) (CBMAB-L2711-YJ)

Provided herein is a Rabbit monoclonal antibody, which binds to Laminin Alpha 2 (Lama2). The antibody can be used for immunoassay techniques, such as FC, ICC, IF.
See all Lama2 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse
Clone
CBYJL-2398
Antibody Isotype
IgG
Application
FC, ICC, IF

Basic Information

Immunogen
Protein corresponding to Human LAMA2 (aa 1170-1380).
Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Preservative
0.09% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1170-1380

Target

Full Name
laminin, alpha 2
Introduction
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Lama2 is laminin subunit alpha-2.
Entrez Gene ID
16773
UniProt ID
Q60675
Alternative Names
dy; mer; merosin; mKIAA4087; 5830440B04; laminin subunit alpha-2; dystrophia muscularis; laminin M chain; laminin-12 subunit alpha; laminin-2 subunit alpha; laminin-4 subunit alpha; merosin heavy chain
Function
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Biological Process
Animal organ morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Cell adhesionIEA:UniProtKB-KW
Maintenance of blood-brain barrier1 PublicationNAS:ARUK-UCL
Muscle organ developmentManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of synaptic transmission, cholinergicIEA:Ensembl
Regulation of cell adhesionIEA:InterPro
Regulation of cell migrationIEA:InterPro
Regulation of embryonic developmentIEA:InterPro
Tissue developmentManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted, extracellular space, extracellular matrix, basement membrane
Major component.
Involvement in disease
Merosin-deficient congenital muscular dystrophy 1A (MDC1A):
Characterized by difficulty walking, hypotonia, proximal weakness, hyporeflexia, and white matter hypodensity on MRI.
Muscular dystrophy, limb-girdle, autosomal recessive 23 (LGMDR23):
A form of autosomal recessive limb-girdle muscular dystrophy, a myopathy characterized by proximal and/or distal muscle weakness and atrophy. The age at onset is variable and can range from the first to the sixth decade, although later onset is less common. LGMDR23 is characterized by slowly progressive proximal muscle weakness primarily affecting the lower limbs, increased serum creatine kinase, dystrophic features, gait difficulties, and white matter abnormalities on brain imaging. Age at onset generally ranges from childhood to mid-adulthood. Some patients may have additional neurologic features, including executive deficits, seizures, and peripheral neuropathy.

Li, S., Hu, J., Li, G., Mai, H., Gao, Y., Liang, B., ... & Duan, Y. (2023). Epigenetic regulation of LINC01270 in breast cancer progression by mediating LAMA2 promoter methylation and MAPK signaling pathway. Cell biology and toxicology, 39(4), 1359-1375.

Tan, D., Ge, L., Fan, Y., Chang, X., Wang, S., Wei, C., ... & Xiong, H. (2021). Natural history and genetic study of LAMA2-related muscular dystrophy in a large Chinese cohort. Orphanet Journal of Rare Diseases, 16(1), 1-12.

Gawlik, K. I., & Durbeej, M. (2020). A family of laminin α2 chain-deficient mouse mutants: advancing the research on LAMA2-CMD. Frontiers in Molecular Neuroscience, 13, 59.

Barraza-Flores, P., Bates, C. R., Oliveira-Santos, A., & Burkin, D. J. (2020). Laminin and integrin in LAMA2-related congenital muscular dystrophy: from disease to therapeutics. Frontiers in molecular neuroscience, 13, 1.

Oliveira, J. P. F. J., Santos, M., & Coelho, T. (2020). LAMA2 muscular dystrophy.

Sarkozy, A., Foley, A. R., Zambon, A. A., Bönnemann, C. G., & Muntoni, F. (2020). LAMA2-related dystrophies: clinical phenotypes, disease biomarkers, and clinical trial readiness. Frontiers in Molecular Neuroscience, 13, 123.

Previtali, S. C., & Zambon, A. A. (2020). LAMA2 neuropathies: human findings and pathomechanisms from mouse models. Frontiers in molecular neuroscience, 13, 60.

Zhu, Y., Zhang, X., Gu, R., Liu, X., Wang, S., Xia, D., ... & Zhou, Y. (2020). LAMA2 regulates the fate commitment of mesenchymal stem cells via hedgehog signaling. Stem cell research & therapy, 11(1), 1-10.

Liang, J., Li, H., Han, J., Jiang, J., Wang, J., Li, Y., ... & Tian, H. (2020). Mex3a interacts with LAMA2 to promote lung adenocarcinoma metastasis via PI3K/AKT pathway. Cell death & disease, 11(8), 614.

Oliveira, J., Gruber, A., Cardoso, M., Taipa, R., Fineza, I., Gonçalves, A., ... & Sousa, M. (2018). LAMA2 gene mutation update: Toward a more comprehensive picture of the laminin‐α2 variome and its related phenotypes. Human mutation, 39(10), 1314-1337.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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