LAMA2

Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene. [provided by RefSeq]
Full Name
laminin, alpha 2
Function
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Biological Process
Animal organ morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Cell adhesionIEA:UniProtKB-KW
Maintenance of blood-brain barrier1 PublicationNAS:ARUK-UCL
Muscle organ developmentManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of synaptic transmission, cholinergicIEA:Ensembl
Regulation of cell adhesionIEA:InterPro
Regulation of cell migrationIEA:InterPro
Regulation of embryonic developmentIEA:InterPro
Tissue developmentManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted, extracellular space, extracellular matrix, basement membrane
Major component.
Involvement in disease
Merosin-deficient congenital muscular dystrophy 1A (MDC1A):
Characterized by difficulty walking, hypotonia, proximal weakness, hyporeflexia, and white matter hypodensity on MRI.
Muscular dystrophy, limb-girdle, autosomal recessive 23 (LGMDR23):
A form of autosomal recessive limb-girdle muscular dystrophy, a myopathy characterized by proximal and/or distal muscle weakness and atrophy. The age at onset is variable and can range from the first to the sixth decade, although later onset is less common. LGMDR23 is characterized by slowly progressive proximal muscle weakness primarily affecting the lower limbs, increased serum creatine kinase, dystrophic features, gait difficulties, and white matter abnormalities on brain imaging. Age at onset generally ranges from childhood to mid-adulthood. Some patients may have additional neurologic features, including executive deficits, seizures, and peripheral neuropathy.
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Anti-LAMA2 antibodies

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Mouse Anti-LAMA2 (AA 3013-3123) Recombinant Antibody (CBFYM-1199) (CBMAB-M1356-FY)

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Target: LAMA2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-1199
Application*: E, P, WB
Datasheet SDS

Mouse Anti-LAMA2 Recombinant Antibody (CBYJL-1086) (CBMAB-L0534-YJ)

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Target: LAMA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Frog
Clone: CBYJL-1086
Application*: WB, P
Datasheet SDS

Rabbit Anti-Lama2 Recombinant Antibody (CBYJL-2398) (CBMAB-L2711-YJ)

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Target: LAMA2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYJL-2398
Application*: F, IC, IF
Datasheet SDS

Rat Anti-Lama2 Recombinant Antibody (CBYJL-2397) (CBMAB-L2710-YJ)

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Target: LAMA2
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYJL-2397
Application*: E, IH, IP
Datasheet SDS

Rat Anti-LAMA2 Recombinant Antibody (CBFYM-1201) (CBMAB-M1358-FY)

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Target: LAMA2
Host: Rat
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBFYM-1201
Application*: E, IH, IP
Datasheet SDS

Mouse Anti-LAMA2 Recombinant Antibody (CBFYM-1200) (CBMAB-M1357-FY)

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Target: LAMA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey, Rabbit
Clone: CBFYM-1200
Application*: E, IF, IH, IP, WB
Datasheet SDS

Mouse Anti-LAMA2 Recombinant Antibody (CBYJL-1084) (CBMAB-L0532-YJ)

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Target: LAMA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBYJL-1084
Application*: IH, WB
Datasheet SDS

Mouse Anti-LAMA2 Recombinant Antibody (CBYJL-1083) (CBMAB-L0531-YJ)

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Target: LAMA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1083
Application*: E, IF, C, IP, WB
Datasheet SDS

Mouse Anti-LAMA2 Recombinant Antibody (CBYJL-1082) (CBMAB-L0530-YJ)

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Target: LAMA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey, Rabbit
Clone: CBYJL-1082
Application*: C, WB, E, IP, IF
Datasheet SDS

Mouse Anti-LAMA2 Recombinant Antibody (CBYJL-1081) (CBMAB-L0528-YJ)

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Target: LAMA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBYJL-1081
Application*: WB, P
Datasheet SDS

Mouse Anti-LAMA2 Recombinant Antibody (2D4) (CBMAB-L0527-YJ)

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Target: LAMA2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2D4
Application*: E, IH, WB
Datasheet SDS

Mouse Anti-LAMA2 Recombinant Antibody (1A7) (CBMAB-L0526-YJ)

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Target: LAMA2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 1A7
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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