Mouse Anti-LAMB1 Recombinant Antibody (CBT2989) (V2LY-0625-LY2274)

Name: Mouse Anti-LAMB1 Recombinant Antibody (CBT2989)
SKU: V2LY-0625-LY2274
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-LAMB1 Recombinant Antibody (CBT2989) (V2LY-0625-LY2274) in WB

Mouse Anti-LAMB1 Recombinant Antibody (CBT2989) (V2LY-0625-LY2274) in IHC

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBT2989

Application

IHC

Immunogen

Purified recombinant fragment of LAMB1 (aa31-270) expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
IHC-P	1:200-1:1,000
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Supernatant

Preservative

Sodium azide

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

LAMB1

Entrez Gene ID

3912

UniProt ID

P07942

Function

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface.

Biological Process

Animal organ morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Basement membrane assemblyManual Assertion Based On ExperimentIBA:GO_Central
Cell adhesionManual Assertion Based On ExperimentTAS:HGNC-UCL
Cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Endodermal cell differentiationManual Assertion Based On ExperimentIEP:UniProtKB
Neuron projection developmentManual Assertion Based On ExperimentIDA:UniProtKB
Neuronal-glial interaction involved in cerebral cortex radial glia guided migrationManual Assertion Based On ExperimentIMP:UniProtKB
OdontogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of epithelial cell proliferationManual Assertion Based On ExperimentTAS:HGNC-UCL
Substrate adhesion-dependent cell spreadingManual Assertion Based On ExperimentIDA:BHF-UCL
Tissue developmentManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Secreted, extracellular space, extracellular matrix, basement membrane
Major component.

Involvement in disease

Lissencephaly 5 (LIS5):
An autosomal recessive brain malformation characterized by cobblestone changes in the cortex, more severe in the posterior region, and subcortical band heterotopia. Affected individuals have hydrocephalus, seizures, and severely delayed psychomotor development.

Toutouna, L., Beck‐Woedl, S., Feige, U., Glaeser, B., Komlosi, K., Eckenweiler, M., ... & Tzschach, A. (2023). Novel homozygous LAMB1 in‐frame deletion in a pediatric patient with brain anomalies and cerebrovascular event. American Journal of Medical Genetics Part A, 191(10), 2656-2663.

Morel, H., Bailly, L., Urbanczyk, C., Hervé, D., Berroir, S., Le Bouc, R., ... & Mathey, G. (2023). Extension of the Clinicoradiologic Spectrum of Newly Described End-Truncating LAMB1 Variations. Neurology: Genetics, 9(3).

Liu, T., Gan, H., He, S., Deng, J., Hu, X., Li, L., ... & Shan, H. (2022). RNA helicase DDX24 stabilizes LAMB1 to promote hepatocellular carcinoma progression. Cancer research, 82(17), 3074-3087.

Bai, M., Chen, H., Zhang, Z., Liu, X., Zhang, D., & Wang, C. (2022). Substrate stiffness promotes dentinogenesis via LAMB1–FAK–MEK1/2 signaling axis. Oral Diseases.

Luo, R., Wang, T., Zhuo, S., Guo, X., & Ma, D. (2022). Excessive hydrogen sulfide causes lung and brain tissue damage by promoting PARP1/Bax and C9 and inhibiting LAMB1. Apoptosis, 27(1-2), 149-160.

Lee, H., Kim, W. J., Kang, H. G., Jang, J. H., Choi, I. J., Chun, K. H., & Kim, S. J. (2021). Upregulation of LAMB1 via ERK/c-Jun axis promotes gastric cancer growth and motility. International journal of molecular sciences, 22(2), 626.

Ran, T., Chen, Z., Zhao, L., Ran, W., Fan, J., Hong, S., & Yang, Z. (2021). LAMB1 is related to the T stage and indicates poor prognosis in gastric cancer. Technology in cancer research & treatment, 20, 15330338211004944.

Aloui, C., Hervé, D., Marenne, G., Savenier, F., Le Guennec, K., Bergametti, F., ... & Tournier‐Lasserve, E. (2021). End‐truncated LAMB1 causes a hippocampal memory defect and a leukoencephalopathy. Annals of Neurology, 90(6), 962-975.

Sen, K., Kaur, S., Stockton, D. W., Nyhuis, M., & Roberson, J. (2021). Biallelic variants in LAMB1 causing Hydranencephaly: a severe phenotype of a rare Malformative encephalopathy. American Journal of Perinatology Reports, 11(01), e26-e28.

Yasuda, R., Yoshida, T., Mizuta, I., Watanabe, M., Nakano, M., Sato, R., ... & Mizuno, T. (2020). Adult-onset leukoencephalopathy with homozygous LAMB1 missense mutation. Neurology: Genetics, 6(4).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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