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Mouse Anti-LAMB1 Recombinant Antibody (CBT2989) (V2LY-0625-LY2274)


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Tested Data
Mouse Anti-LAMB1 Recombinant Antibody (CBT2989) (V2LY-0625-LY2274) in WB
Mouse Anti-LAMB1 Recombinant Antibody (CBT2989) (V2LY-0625-LY2274) in WB
Mouse Anti-LAMB1 Recombinant Antibody (CBT2989) (V2LY-0625-LY2274) in IHC
Mouse Anti-LAMB1 Recombinant Antibody (CBT2989) (V2LY-0625-LY2274) in IHC

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT2989
Antibody Isotype
IgG2a
Application
IHC

Basic Information

Immunogen
Purified recombinant fragment of LAMB1 (aa31-270) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Preservative
Sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
LAMB1
Entrez Gene ID
3912
UniProt ID
P07942
Function
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface.
Biological Process
Animal organ morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Basement membrane assemblyManual Assertion Based On ExperimentIBA:GO_Central
Cell adhesionManual Assertion Based On ExperimentTAS:HGNC-UCL
Cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Endodermal cell differentiationManual Assertion Based On ExperimentIEP:UniProtKB
Neuron projection developmentManual Assertion Based On ExperimentIDA:UniProtKB
Neuronal-glial interaction involved in cerebral cortex radial glia guided migrationManual Assertion Based On ExperimentIMP:UniProtKB
OdontogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of epithelial cell proliferationManual Assertion Based On ExperimentTAS:HGNC-UCL
Substrate adhesion-dependent cell spreadingManual Assertion Based On ExperimentIDA:BHF-UCL
Tissue developmentManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted, extracellular space, extracellular matrix, basement membrane
Major component.
Involvement in disease
Lissencephaly 5 (LIS5):
An autosomal recessive brain malformation characterized by cobblestone changes in the cortex, more severe in the posterior region, and subcortical band heterotopia. Affected individuals have hydrocephalus, seizures, and severely delayed psychomotor development.
More Infomation

Toutouna, L., Beck‐Woedl, S., Feige, U., Glaeser, B., Komlosi, K., Eckenweiler, M., ... & Tzschach, A. (2023). Novel homozygous LAMB1 in‐frame deletion in a pediatric patient with brain anomalies and cerebrovascular event. American Journal of Medical Genetics Part A, 191(10), 2656-2663.

Morel, H., Bailly, L., Urbanczyk, C., Hervé, D., Berroir, S., Le Bouc, R., ... & Mathey, G. (2023). Extension of the Clinicoradiologic Spectrum of Newly Described End-Truncating LAMB1 Variations. Neurology: Genetics, 9(3).

Liu, T., Gan, H., He, S., Deng, J., Hu, X., Li, L., ... & Shan, H. (2022). RNA helicase DDX24 stabilizes LAMB1 to promote hepatocellular carcinoma progression. Cancer research, 82(17), 3074-3087.

Bai, M., Chen, H., Zhang, Z., Liu, X., Zhang, D., & Wang, C. (2022). Substrate stiffness promotes dentinogenesis via LAMB1–FAK–MEK1/2 signaling axis. Oral Diseases.

Luo, R., Wang, T., Zhuo, S., Guo, X., & Ma, D. (2022). Excessive hydrogen sulfide causes lung and brain tissue damage by promoting PARP1/Bax and C9 and inhibiting LAMB1. Apoptosis, 27(1-2), 149-160.

Lee, H., Kim, W. J., Kang, H. G., Jang, J. H., Choi, I. J., Chun, K. H., & Kim, S. J. (2021). Upregulation of LAMB1 via ERK/c-Jun axis promotes gastric cancer growth and motility. International journal of molecular sciences, 22(2), 626.

Ran, T., Chen, Z., Zhao, L., Ran, W., Fan, J., Hong, S., & Yang, Z. (2021). LAMB1 is related to the T stage and indicates poor prognosis in gastric cancer. Technology in cancer research & treatment, 20, 15330338211004944.

Aloui, C., Hervé, D., Marenne, G., Savenier, F., Le Guennec, K., Bergametti, F., ... & Tournier‐Lasserve, E. (2021). End‐truncated LAMB1 causes a hippocampal memory defect and a leukoencephalopathy. Annals of Neurology, 90(6), 962-975.

Sen, K., Kaur, S., Stockton, D. W., Nyhuis, M., & Roberson, J. (2021). Biallelic variants in LAMB1 causing Hydranencephaly: a severe phenotype of a rare Malformative encephalopathy. American Journal of Perinatology Reports, 11(01), e26-e28.

Yasuda, R., Yoshida, T., Mizuta, I., Watanabe, M., Nakano, M., Sato, R., ... & Mizuno, T. (2020). Adult-onset leukoencephalopathy with homozygous LAMB1 missense mutation. Neurology: Genetics, 6(4).

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For research use only. Not intended for any clinical use.

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