Mouse Anti-LAMP1 Recombinant Antibody (CBYJL-1147) (CBMAB-L0627-YJ)

Name: Mouse Anti-LAMP1 Recombinant Antibody (CBYJL-1147)
SKU: CBMAB-L0627-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYJL-1147

Application

WB, IP

Immunogen

Human Lamp-1 aa 25-224.

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 25-224

More Infomation

Target

Full Name

LAMP1

Introduction

LAMP1 is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. LAMP1 may also play a role in tumor cell metastasis. Diseases associated with LAMP1 include Salla Disease and Hermansky-Pudlak Syndrome 2. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Cytoskeletal Signaling.

Entrez Gene ID

3916

UniProt ID

P11279

Alternative Names

CD107a; LAMPA; LGP120

Function

Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, autophagy, and cholesterol homeostasis (By similarity).
Plays also an important role in NK-cells cytotoxicity (PubMed:23632890, PubMed:2022921).
Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule (PubMed:23632890).
In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content (PubMed:23847195).
Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.
(Microbial infection) Acts as a receptor for Lassa virus glycoprotein (PubMed:24970085).
Promotes also fusion of the virus with host membrane in less acidic endosomes (PubMed:29295909).
(Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F.

Biological Process

Establishment of protein localization to organelleManual Assertion Based On ExperimentIMP:UniProtKB
Golgi to lysosome transportManual Assertion Based On ExperimentIMP:UniProtKB
Granzyme-mediated programmed cell death signaling pathwayManual Assertion Based On ExperimentIMP:GO_Central
Positive regulation of natural killer cell degranulationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIMP:UniProtKB
Protein stabilizationISS:CAFA
Regulation of organelle transport along microtubuleManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cell membrane
Endosome membrane
Lysosome membrane
Late endosome membrane
Cytolytic granule membrane
This protein shuttles between lysosomes, endosomes, and the plasma membrane (By similarity).
Colocalizes with OSBPL1A at the late endosome (PubMed:16176980).

Topology

Lumenal: 29-382
Helical: 383-405
Cytoplasmic: 406-417

PTM

O- and N-glycosylated; some of the 18 N-linked glycans are polylactosaminoglycans. The glycosylation of N-76 is essential for Lassa virus entry into cells.

Chaudhry, N., Sica, M., Surabhi, S., Hernandez, D. S., Mesquita, A., Selimovic, A., ... & Jenny, A. (2022). Lamp1 mediates lipid transport, but is dispensable for autophagy in Drosophila. Autophagy, 18(10), 2443-2458.

Nassal, J. P., Murphy, F. H., Toonen, R. F., & Verhage, M. (2022). Differential axonal trafficking of Neuropeptide Y-, LAMP1-, and RAB7-tagged organelles in vivo. Elife, 11, e81721.

Baba, K., Kuwada, S., Nakao, A., Li, X., Okuda, N., Nishida, A., ... & Kataoka, T. (2020). Different localization of lysosomal-associated membrane protein 1 (LAMP1) in mammalian cultured cell lines. Histochemistry and cell biology, 153, 199-213.

Chen, H., Li, L., Hu, J., Zhao, Z., Ji, L., Cheng, C., ... & Sun, B. (2019). UBL4A inhibits autophagy-mediated proliferation and metastasis of pancreatic ductal adenocarcinoma via targeting LAMP1. Journal of Experimental & Clinical Cancer Research, 38, 1-18.

Deng, L., Liu, G., Zheng, C., Zhang, L., Kang, Y., & Yang, F. (2019). Circ-LAMP1 promotes T-cell lymphoblastic lymphoma progression via acting as a ceRNA for miR-615-5p to regulate DDR2 expression. Gene, 701, 146-151.

Wang, X., Li, C., Wang, Q., Li, W., Guo, D., Zhang, X., ... & Wang, Y. (2019). Tanshinone IIA restores dynamic balance of autophagosome/autolysosome in doxorubicin-induced cardiotoxicity via targeting beclin1/LAMP1. Cancers, 11(7), 910.

Hulseberg, C. E., Fénéant, L., Szymańska, K. M., & White, J. M. (2018). Lamp1 increases the efficiency of Lassa virus infection by promoting fusion in less acidic endosomal compartments. MBio, 9(1), 10-1128.

Cheng, X. T., Xie, Y. X., Zhou, B., Huang, N., Farfel-Becker, T., & Sheng, Z. H. (2018). Characterization of LAMP1-labeled nondegradative lysosomal and endocytic compartments in neurons. Journal of Cell Biology, 217(9), 3127-3139.

Cheng, X. T., Xie, Y. X., Zhou, B., Huang, N., Farfel-Becker, T., & Sheng, Z. H. (2018). Revisiting LAMP1 as a marker for degradative autophagy-lysosomal organelles in the nervous system. Autophagy, 14(8), 1472-1474.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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For research use only. Not intended for any clinical use.

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