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LAMP1

The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis.
Full Name
LAMP1
Function
Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, autophagy, and cholesterol homeostasis (By similarity).
Plays also an important role in NK-cells cytotoxicity (PubMed:23632890, PubMed:2022921).
Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule (PubMed:23632890).
In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content (PubMed:23847195).
Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.
(Microbial infection) Acts as a receptor for Lassa virus glycoprotein (PubMed:24970085).
Promotes also fusion of the virus with host membrane in less acidic endosomes (PubMed:29295909).
(Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F.
Biological Process
Establishment of protein localization to organelleManual Assertion Based On ExperimentIMP:UniProtKB
Golgi to lysosome transportManual Assertion Based On ExperimentIMP:UniProtKB
Granzyme-mediated programmed cell death signaling pathwayManual Assertion Based On ExperimentIMP:GO_Central
Positive regulation of natural killer cell degranulationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIMP:UniProtKB
Protein stabilizationISS:CAFA
Regulation of organelle transport along microtubuleManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cell membrane
Endosome membrane
Lysosome membrane
Late endosome membrane
Cytolytic granule membrane
This protein shuttles between lysosomes, endosomes, and the plasma membrane (By similarity).
Colocalizes with OSBPL1A at the late endosome (PubMed:16176980).
Topology
Lumenal: 29-382
Helical: 383-405
Cytoplasmic: 406-417
PTM
O- and N-glycosylated; some of the 18 N-linked glycans are polylactosaminoglycans. The glycosylation of N-76 is essential for Lassa virus entry into cells.

Anti-LAMP1 antibodies

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Target: LAMP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: B-T47
Application*: F
Target: LAMP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Rat, Mouse, Hamster
Clone: LY1C6
Application*: IP, IC, IF, WB
Target: LAMP1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 1D4B
Application*: E, IF, IH, IP, WB
Target: LAMP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Hamster, Rat
Clone: H4A3
Application*: IF, IH, WB
Target: LAMP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: G1/139/5
Application*: IF, IP, WB
Target: LAMP1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBWJC-4114
Application*: B, IF
Target: LAMP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4111
Application*: E
Target: LAMP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: B-K9
Application*: IC, F
Target: LAMP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4110
Application*: F
Target: LAMP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Rat
Clone: CBWJC-2319
Application*: F, C, IP, WB
Target: LAMP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJC-2318
Application*: F, IC, IF, P, WB
Target: LAMP1
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBWJC-2317
Application*: F, C, P, IP, WB
Target: LAMP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: B-N8
Application*: E, F, FN, IH
Target: LAMP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-1865
Application*: F
Target: LAMP1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYC-0386
Application*: F
Target: LAMP1
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBYJL-2523
Application*: F, C, P, IP, WB
Target: LAMP1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYJL-2522
Application*: IC
Target: LAMP1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYJL-2521
Application*: IC
Target: LAMP1
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBYJL-2520
Application*: F, IH, IP, WB
Target: LAMP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1159
Application*: F
Target: LAMP1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1158
Application*: WB, IP, IF
Target: LAMP1
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBYJL-1157
Application*: WB, P
Target: LAMP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJL-1156
Application*: F
Target: LAMP1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJL-1155
Application*: WB, P
Target: LAMP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: CBYJL-1153
Application*: WB, IP, P, IF
Target: LAMP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Monkey
Clone: CBYJL-1152
Application*: WB
Target: LAMP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 9H151
Application*: F
Target: LAMP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9A179
Application*: F
Target: LAMP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Pig, Cattle
Clone: 6E2
Application*: WB, IC, IF
Target: LAMP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5K76
Application*: F, IH
Target: LAMP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Pig, Cattle
Clone: 5H6
Application*: WB, IC, IF
Target: LAMP1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYJL-1150
Application*: WB, IH, IC, IF, P
Target: LAMP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJL-1149
Application*: F
Target: LAMP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Hamster, Rat
Clone: 4E151
Application*: IC, IF, IP, WB
Target: LAMP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJL-1147
Application*: WB, IP
Target: LAMP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1483CT517.45.23
Application*: E, WB
Target: LAMP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Cattle, Mouse, Pig, Rat
Clone: CBYJL-1145
Application*: IF, WB
Target: LAMP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJL-1144
Application*: F, IC, WB
Target: LAMP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1143
Application*: WB
Target: LAMP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1142
Application*: N
Target: LAMP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1141
Application*: F
Target: LAMP1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1140
Application*: EC
Target: LAMP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Hamster, Human, Mouse, Rat
Clone: A860
Application*: ICC/IF, IP, WB
Target: LAMP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Monkey
Clone: C54H11
Application*: WB
Target: LAMP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Human, Mouse, Rat
Clone: CBYY-C2633
Application*: IF, WB
Target: LAMP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig
Clone: 4E9/11
Application*: C, F, IP, P, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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