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Mouse Anti-LAMP1 Recombinant Antibody (A860) (CBMAB-AP11312LY)

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Datasheet
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Basic Information

Host Animal
Mouse
Clone
A860
Application
ICC/IF, IP, WB
Immunogen
Rat liver lysosomal membrane preparations
Specificity
Hamster, Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
LAMP1
Entrez Gene ID
Human3916
Mouse16783
Rat25328
Hamster100689406
UniProt ID
HumanP11279
MouseP11438
RatP14562
HamsterP49129
Alternative Names
CD107 Antibody, CD107a Antibody, LAMPA Antibody, LGP120 Antibody, IgpA Antibody, Lysosome-associated membrane glycoprotein 1 Antibody, CD107 antigen-like family member A Antibody, 120 kDa lysosomal membrane glycoprotein Antibody, Lamp-1 Antibody
Function
SMC-140D
Biological Process
Establishment of protein localization to organelleManual Assertion Based On ExperimentIMP:UniProtKB
Golgi to lysosome transportManual Assertion Based On ExperimentIMP:UniProtKB
Granzyme-mediated programmed cell death signaling pathwayManual Assertion Based On ExperimentIMP:GO_Central
Positive regulation of natural killer cell degranulationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIMP:UniProtKB
Protein stabilizationISS:CAFA
Regulation of organelle transport along microtubuleManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cell membrane
Endosome membrane
Lysosome membrane
Late endosome membrane
Cytolytic granule membrane
This protein shuttles between lysosomes, endosomes, and the plasma membrane (By similarity).
Colocalizes with OSBPL1A at the late endosome (PubMed:16176980).
Topology
Lumenal: 29-382
Helical: 383-405
Cytoplasmic: 406-417
PTM
O- and N-glycosylated; some of the 18 N-linked glycans are polylactosaminoglycans. The glycosylation of N-76 is essential for Lassa virus entry into cells.

Chaudhry, N., Sica, M., Surabhi, S., Hernandez, D. S., Mesquita, A., Selimovic, A., ... & Jenny, A. (2022). Lamp1 mediates lipid transport, but is dispensable for autophagy in Drosophila. Autophagy, 18(10), 2443-2458.

Nassal, J. P., Murphy, F. H., Toonen, R. F., & Verhage, M. (2022). Differential axonal trafficking of Neuropeptide Y-, LAMP1-, and RAB7-tagged organelles in vivo. Elife, 11, e81721.

Baba, K., Kuwada, S., Nakao, A., Li, X., Okuda, N., Nishida, A., ... & Kataoka, T. (2020). Different localization of lysosomal-associated membrane protein 1 (LAMP1) in mammalian cultured cell lines. Histochemistry and cell biology, 153, 199-213.

Chen, H., Li, L., Hu, J., Zhao, Z., Ji, L., Cheng, C., ... & Sun, B. (2019). UBL4A inhibits autophagy-mediated proliferation and metastasis of pancreatic ductal adenocarcinoma via targeting LAMP1. Journal of Experimental & Clinical Cancer Research, 38, 1-18.

Deng, L., Liu, G., Zheng, C., Zhang, L., Kang, Y., & Yang, F. (2019). Circ-LAMP1 promotes T-cell lymphoblastic lymphoma progression via acting as a ceRNA for miR-615-5p to regulate DDR2 expression. Gene, 701, 146-151.

Wang, X., Li, C., Wang, Q., Li, W., Guo, D., Zhang, X., ... & Wang, Y. (2019). Tanshinone IIA restores dynamic balance of autophagosome/autolysosome in doxorubicin-induced cardiotoxicity via targeting beclin1/LAMP1. Cancers, 11(7), 910.

Hulseberg, C. E., Fénéant, L., Szymańska, K. M., & White, J. M. (2018). Lamp1 increases the efficiency of Lassa virus infection by promoting fusion in less acidic endosomal compartments. MBio, 9(1), 10-1128.

Cheng, X. T., Xie, Y. X., Zhou, B., Huang, N., Farfel-Becker, T., & Sheng, Z. H. (2018). Characterization of LAMP1-labeled nondegradative lysosomal and endocytic compartments in neurons. Journal of Cell Biology, 217(9), 3127-3139.

Cheng, X. T., Xie, Y. X., Zhou, B., Huang, N., Farfel-Becker, T., & Sheng, Z. H. (2018). Revisiting LAMP1 as a marker for degradative autophagy-lysosomal organelles in the nervous system. Autophagy, 14(8), 1472-1474.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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