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Mouse Anti-LAMP2 Recombinant Antibody (A863) (CBMAB-AP3784LY)


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Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
A863
Antibody Isotype
IgG
Application
ICC, IHC, IP, WB

Basic Information

Specificity
Human, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Entrez Gene ID
Human3920
Rat24944
UniProt ID
HumanP13473
RatP17046
Alternative Names
CD107B, INDO, Indoleamine-Pyrrole 2,3 Dioxygenase
Function
MAB547Hu22
Biological Process
Autophagosome maturationISS:UniProtKB
Cellular response to starvationISS:UniProtKB
Chaperone-mediated autophagyManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Establishment of protein localization to organelleManual Assertion Based On ExperimentIBA:GO_Central
Lysosomal protein catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Muscle cell cellular homeostasisIEA:Ensembl
Negative regulation of protein-containing complex assemblyIDA:ParkinsonsUK-UCL
Protein importManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Protein stabilizationISS:CAFA
Protein targetingISS:UniProtKB
Protein targeting to lysosome involved in chaperone-mediated autophagyManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of protein stabilityManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Cellular Location
Cell membrane
Endosome membrane
Lysosome membrane
Cytoplasmic vesicle, autophagosome membrane
This protein shuttles between lysosomes, endosomes, and the plasma membrane.
Involvement in disease
Danon disease (DAND):
DAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle and lysosomes.
Topology
Lumenal: 29-375
Helical: 376-399
Cytoplasmic: 400-410
PTM
O- and N-glycosylated; some of the 16 N-linked glycans are polylactosaminoglycans.
More Infomation

Yam, J. C., Zhang, X. J., Zhang, Y., Yip, B. H., Tang, F., Wong, E. S., ... & Pang, C. P. (2023). Effect of low-concentration atropine eyedrops vs placebo on myopia incidence in children: the LAMP2 randomized clinical trial. JAMA, 329(6), 472-481.

Liu, D., Xing, R., Zhang, Q., Tian, X., Qi, Y., Song, H., ... & Han, Y. (2023). The CREG1-FBXO27-LAMP2 axis alleviates diabetic cardiomyopathy by promoting autophagy in cardiomyocytes. Experimental & Molecular Medicine, 55(9), 2025-2038.

Rodrigues, P. M., Sousa, L. G., Perrod, C., Maceiras, A. R., Ferreirinha, P., Pombinho, R., ... & Alves, N. L. (2023). LAMP2 regulates autophagy in the thymic epithelium and thymic stroma-dependent CD4 T cell development. Autophagy, 19(2), 426-439.

Alcalai, R., Arad, M., Wakimoto, H., Yadin, D., Gorham, J., Wang, L., ... & Seidman, C. E. (2021). LAMP2 cardiomyopathy: consequences of impaired autophagy in the heart. Journal of the American Heart Association, 10(17), e018829.

Huang, P. S., Lin, Y. H., Chi, H. C., Tseng, Y. H., Chen, C. Y., Lin, T. K., ... & Lin, K. H. (2020). Dysregulated FAM215A stimulates LAMP2 expression to confer drug-resistant and malignant in human liver cancer. Cells, 9(4), 961.

Ye, G., Wu, H., Huang, J., Wang, W., Ge, K., Li, G., ... & Huang, Q. (2020). LAMP2: a major update of the database linking antimicrobial peptides. Database, 2020, baaa061.

Cui, L., Zhao, L. P., Ye, J. Y., Yang, L., Huang, Y., Jiang, X. P., ... & Huang, Y. (2020). The lysosomal membrane protein Lamp2 alleviates lysosomal cell death by promoting autophagic flux in ischemic cardiomyocytes. Frontiers in Cell and Developmental Biology, 8, 31.

Notomi, S., Ishihara, K., Efstathiou, N. E., Lee, J. J., Hisatomi, T., Tachibana, T., ... & Vavvas, D. G. (2019). Genetic LAMP2 deficiency accelerates the age-associated formation of basal laminar deposits in the retina. Proceedings of the National Academy of Sciences, 116(47), 23724-23734.

Dubois, A., Furstoss, N., Calleja, A., Zerhouni, M., Cluzeau, T., Savy, C., ... & Robert, G. (2019). RETRACTED ARTICLE: LAMP2 expression dictates azacytidine response and prognosis in MDS/AML. Leukemia, 33(6), 1501-1513.

Klaver, A. C., Coffey, M. P., Aasly, J. O., & Loeffler, D. A. (2018). CSF lamp2 concentrations are decreased in female Parkinson’s disease patients with LRRK2 mutations. Brain Research, 1683, 12-16.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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