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Rabbit Anti-LAMTOR2 Recombinant Antibody (CBYJL-1178) (CBMAB-L0677-YJ)

Provided herein is a Rabbit monoclonal antibody, which binds to Late Endosomal/Lysosomal Adaptor Mapk And Mtor Activator 2 (LAMTOR2). The antibody can be used for immunoassay techniques, such as WB, IP.
See all LAMTOR2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Clone
CBYJL-1178
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
Introduction
LAMTOR2 is highly conserved with a mouse protein associated with the cytoplasmic face of late endosomes and lysosomes. The mouse protein interacts with MAPK scaffold protein 1, a component of the mitogen-activated protein kinase pathway. In humans, a mutation in LAMTOR2 has been associated with a primary immunodeficiency syndrome, and suggests a role for this protein in endosomal biogenesis. Multiple transcript variants encoding different isoforms have been described for this gene. Among its related pathways are Gene Expression and RET signaling.
Entrez Gene ID
Human28956
Mouse83409
Rat295234
Monkey718110
UniProt ID
HumanQ9Y2Q5
MouseQ9JHS3
RatD4A465
MonkeyG7NV75
Alternative Names
ENDAP; HSPC003; MAPBPIP; MAPKSP1AP; ROBLD3; Ragulator2; p14
Function
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
Biological Process
Cellular protein localizationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular response to amino acid stimulusManual Assertion Based On ExperimentIDA:ComplexPortal
Fibroblast migrationIEA:Ensembl
Positive regulation of MAPK cascadeIEA:Ensembl
Positive regulation of TOR signalingManual Assertion Based On ExperimentIMP:UniProtKB
Protein localization to cell junctionIEA:Ensembl
Regulation of cell growthManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of cell-substrate junction organizationManual Assertion Based On ExperimentIMP:MGI
Cellular Location
Late endosome membrane
Lysosome membrane
Involvement in disease
Immunodeficiency due to defect in MAPBP-interacting protein (ID-MAPBPIP):
This form of primary immunodeficiency syndrome includes congenital neutropenia, partial albinism, short stature and B-cell and cytotoxic T-cell deficiency.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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