Human Recombinant LAMTOR2 protein, His Tag (V2LY-0526-LY5251)

Name: Human Recombinant LAMTOR2 protein, His Tag
SKU: V2LY-0526-LY5251
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant LAMTOR2 protein, His Tag consist of Amino Acid: 1-125 and predicts a molecular mass of 15 kDa.

Molecule Mass

15 kDa

Sequence

Amino Acid: 1-125

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>97% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

late endosomal/lysosomal adaptor, MAPK and MTOR activator 2

Function

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.

Biological Process

Cellular protein localizationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular response to amino acid stimulusManual Assertion Based On ExperimentIDA:ComplexPortal
Fibroblast migrationIEA:Ensembl
Positive regulation of MAPK cascadeIEA:Ensembl
Positive regulation of TOR signalingManual Assertion Based On ExperimentIMP:UniProtKB
Protein localization to cell junctionIEA:Ensembl
Regulation of cell growthManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of cell-substrate junction organizationManual Assertion Based On ExperimentIMP:MGI

Cellular Location

Late endosome membrane
Lysosome membrane

Involvement in disease

Immunodeficiency due to defect in MAPBP-interacting protein (ID-MAPBPIP):
This form of primary immunodeficiency syndrome includes congenital neutropenia, partial albinism, short stature and B-cell and cytotoxic T-cell deficiency.

Xu, J., Quan, G., Huang, W., & Jiang, J. (2023). VSIG2 promotes malignant progression of pancreatic ductal adenocarcinoma by enhancing LAMTOR2-mediated mTOR activation. Cell Communication and Signaling, 21(1), 223.

Wu, T., Li, H., Su, C., Xu, F., Yang, G., Sun, K., ... & Li, J. (2020). Microbiota-derived short-chain fatty acids promote LAMTOR2-mediated immune responses in macrophages. Msystems, 5(6), 10-1128.

Lin, C. Y., Nozawa, T., Minowa‐Nozawa, A., Toh, H., Aikawa, C., & Nakagawa, I. (2019). LAMTOR2/LAMTOR1 complex is required for TAX1BP1‐mediated xenophagy. Cellular microbiology, 21(4), e12981.

Łyszkiewicz, M., Kotlarz, D., Ziȩtara, N., Brandes, G., Diestelhorst, J., Glage, S., ... & Klein, C. (2019). LAMTOR2 (p14) controls B cell differentiation by orchestrating endosomal BCR trafficking. Frontiers in Immunology, 10, 497.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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