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Mouse Anti-LANCL1 Recombinant Antibody (CBYJL-1183) (CBMAB-L0683-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Lanc Like 1 (LANCL1). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all LANCL1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJL-1183
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
LanC lantibiotic synthetase component C-like 1 (bacterial)
Introduction
LANCL1 is a loosely associated peripheral membrane protein related to the LanC family of bacterial membrane-associated proteins involved in the biosynthesis of antimicrobial peptides. This protein may function as a peptide-modifying enzyme component in eukaryotic cells. Previously considered a member of the G-protein-coupled receptor superfamily, LANCL1 is now in the LanC family. Multiple alternatively spliced variants, encoding the same protein, have been found.
Entrez Gene ID
10314
UniProt ID
O43813
Alternative Names
GPR69A; p40
Function
Functions as glutathione transferase. Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrophenyl acetate. Mitigates neuronal oxidative stress during normal postnatal development and in response to oxidative stresses probably through GSH antioxidant defense mechanism (By similarity).
May play a role in EPS8 signaling. Binds glutathione (PubMed:19528316).
Biological Process
Carbohydrate metabolic processIEA:InterPro
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Regulation of neuron apoptotic processISS:UniProtKB
Regulation of oxidative stress-induced neuron deathISS:UniProtKB
Cellular Location
Cytoplasm
Cell membrane

Spinelli, S., Guida, L., Passalacqua, M., Magnone, M., Cossu, V., Sambuceti, G., ... & Zocchi, E. (2023). Abscisic Acid and Its Receptors LANCL1 and LANCL2 Control Cardiomyocyte Mitochondrial Function, Expression of Contractile, Cytoskeletal and Ion Channel Proteins and Cell Proliferation via ERRα. Antioxidants, 12(9), 1692.

Spinelli, S., Cossu, V., Passalacqua, M., Hansen, J. B., Guida, L., Magnone, M., ... & Zocchi, E. (2023). The ABA/LANCL1/2 Hormone/Receptor System Controls Adipocyte Browning and Energy Expenditure. International Journal of Molecular Sciences, 24(4), 3489.

Spinelli, S., Guida, L., Vigliarolo, T., Passalacqua, M., Begani, G., Magnone, M., ... & Zocchi, E. (2022). The ABA-LANCL1/2 Hormone-Receptors System Protects H9c2 Cardiomyocytes from Hypoxia-Induced Mitochondrial Injury via an AMPK-and NO-Mediated Mechanism. Cells, 11(18), 2888.

Huang, C., Yang, C., Pang, D., Li, C., Gong, H., Cao, X., ... & Chen, Z. (2022). Animal models of male subfertility targeted on LanCL1-regulated spermatogenic redox homeostasis. Lab Animal, 51(5), 133-145.

Spinelli, S., Begani, G., Guida, L., Magnone, M., Galante, D., D'Arrigo, C., ... & Sturla, L. (2021). LANCL1 binds abscisic acid and stimulates glucose transport and mitochondrial respiration in muscle cells via the AMPK/PGC-1α/Sirt1 pathway. Molecular Metabolism, 53, 101263.

Tan, H., Chen, M., Pang, D., Xia, X., Du, C., Yang, W., ... & Xiao, B. (2020). LanCL1 promotes motor neuron survival and extends the lifespan of amyotrophic lateral sclerosis mice. Cell Death & Differentiation, 27(4), 1369-1382.

Downey, A., Olcott, M., Spector, D., Bird, K., Ter Doest, A., Pierce, Z., ... & Hensley, K. (2020). Stable knockout of lanthionine synthase C-like protein-1 (LanCL1) from HeLa cells indicates a role for LanCL1 in redox regulation of deubiquitinating enzymes. Free Radical Biology and Medicine, 161, 115-124.

Zhang, F., Qi, N., Zeng, Y., Bao, M., Chen, Y., Liao, J., ... & Mo, Z. (2020). The endogenous alterations of the gut microbiota and feces metabolites alleviate oxidative damage in the brain of LanCL1 knockout mice. Frontiers in Microbiology, 11, 557342.

Xie, Z., Cao, B. Q., Wang, T., Lei, Q., Kang, T., Ge, C. Y., ... & Hui, H. (2018). LanCL1 attenuates ischemia-induced oxidative stress by Sirt3-mediated preservation of mitochondrial function. Brain Research Bulletin, 142, 216-223.

Wang, J., Xiao, Q., Chen, X., Tong, S., Sun, J., Lv, R., ... & Ding, G. (2018). LanCL1 protects prostate cancer cells from oxidative stress via suppression of JNK pathway. Cell Death & Disease, 9(2), 197.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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