LANCL1

This gene encodes a loosely associated peripheral membrane protein related to the LanC family of bacterial membrane-associated proteins involved in the biosynthesis of antimicrobial peptides. This protein may play a role as a peptide-modifying enzyme component in eukaryotic cells. Previously considered a member of the G-protein-coupled receptor superfamily, this protein is now in the LanC family. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq]

Full Name

LanC lantibiotic synthetase component C-like 1 (bacterial)

Function

Functions as glutathione transferase. Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrophenyl acetate. Mitigates neuronal oxidative stress during normal postnatal development and in response to oxidative stresses probably through GSH antioxidant defense mechanism (By similarity).
May play a role in EPS8 signaling. Binds glutathione (PubMed:19528316).

Biological Process

Carbohydrate metabolic processIEA:InterPro
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Regulation of neuron apoptotic processISS:UniProtKB
Regulation of oxidative stress-induced neuron deathISS:UniProtKB

Cellular Location

Cytoplasm
Cell membrane