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Mouse Anti-LBX1 Recombinant Antibody (CBYJL-1238) (CBMAB-L0772-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Ladybird Homeobox 1 (LBX1). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all LBX1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJL-1238
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Recombinant corresponding to aa 133-219 from LBX1 (NP_006553) with GST tag. MW of the GST tag alone is 26kD.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 133-219

Target

Full Name
LBX1
Introduction
Diseases associated with LBX1 include Idiopathic Scoliosis and Split-Hand/Foot Malformation 3. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is LBX2.Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord.
Entrez Gene ID
10660
UniProt ID
P52954
Alternative Names
HPX-6; HPX6H; homeobox; LBX1
Function
Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord.
Biological Process
Anatomical structure morphogenesisManual Assertion Based On ExperimentTAS:ProtInc
Heart loopingIEA:Ensembl
Muscle organ developmentIEA:UniProtKB-KW
Negative regulation of cell population proliferationIEA:Ensembl
Negative regulation of neuron differentiationIEA:Ensembl
Neuron fate determinationIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Spinal cord motor neuron differentiationIEA:Ensembl
Cellular Location
Nucleus

Matsuhashi, Y., Horiuchi, K., Nakagawa, T., Takahashi, Y., Imabayashi, H., Hosogane, N., ... & Chiba, K. (2023). Abrogation of LBX1 in skeletal muscle results in hypoplastic limbs and progressive kyphosis in mice. Journal of Orthopaedic Research®, 41(4), 884-890.

Janusz, P., Tokłowicz, M., Andrusiewicz, M., Kotwicka, M., & Kotwicki, T. (2022). Association of LBX1 Gene Methylation Level with Disease Severity in Patients with Idiopathic Scoliosis: Study on Deep Paravertebral Muscles. Genes, 13(9), 1556.

Schinzel, F., Seyfer, H., Ebbers, L., & Nothwang, H. G. (2021). The Lbx1 lineage differentially contributes to inhibitory cell types of the dorsal cochlear nucleus, a cerebellum‐like structure, and the cerebellum. Journal of Comparative Neurology, 529(11), 3032-3045.

Sircombe, K. J. (2019). The role of Lbx1 expression in a mouse model of Adolescent Idiopathic Scoliosis (Doctoral dissertation, University of Otago).

Jennings, W., Hou, M., Perterson, D., Missiuna, P., Thabane, L., Tarnopolsky, M., & Samaan, M. C. (2019). Paraspinal muscle ladybird homeobox 1 (LBX1) in adolescent idiopathic scoliosis: A cross-sectional study. The Spine Journal, 19(12), 1911-1916.

Jiang, H., Yang, Q., Liu, Y., Guan, Y., Zhan, X., Xiao, Z., & Wei, Q. (2019). Association between ladybird homeobox 1 gene polymorphisms and adolescent idiopathic scoliosis: A MOOSE-compliant meta-analysis. Medicine, 98(27), e16314.

Nada, D., Julien, C., Samuels, M. E., & Moreau, A. (2018). A Replication Study for Association of LBX1 Locus With Adolescent Idiopathic Scoliosis in French–Canadian Population. Spine, 43(3), 172-178.

Nikolova, S., Dikova, M., Dikov, D., Djerov, A., Savov, A., Kremensky, I., & Loukanov, A. (2018). Positive association between the progression of idiopathic scoliosis and the common variant near the LBX1 gene in Southeast European population. Journal of Applied Biomedicine, 16(4), 344-349.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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