Mouse Anti-LBX1 Recombinant Antibody (CBYJL-1238) (CBMAB-L0772-YJ)

Name: Mouse Anti-LBX1 Recombinant Antibody (CBYJL-1238)
SKU: CBMAB-L0772-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYJL-1238

Application

ELISA, WB

Immunogen

Recombinant corresponding to aa 133-219 from LBX1 (NP_006553) with GST tag. MW of the GST tag alone is 26kD.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.2

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 133-219

More Infomation

Target

Full Name

LBX1

Introduction

Diseases associated with LBX1 include Idiopathic Scoliosis and Split-Hand/Foot Malformation 3. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is LBX2.Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord.

Entrez Gene ID

10660

UniProt ID

P52954

Alternative Names

HPX-6; HPX6H; homeobox; LBX1

Function

Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord.

Biological Process

Anatomical structure morphogenesisManual Assertion Based On ExperimentTAS:ProtInc
Heart loopingIEA:Ensembl
Muscle organ developmentIEA:UniProtKB-KW
Negative regulation of cell population proliferationIEA:Ensembl
Negative regulation of neuron differentiationIEA:Ensembl
Neuron fate determinationIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Spinal cord motor neuron differentiationIEA:Ensembl

Cellular Location

Nucleus

Matsuhashi, Y., Horiuchi, K., Nakagawa, T., Takahashi, Y., Imabayashi, H., Hosogane, N., ... & Chiba, K. (2023). Abrogation of LBX1 in skeletal muscle results in hypoplastic limbs and progressive kyphosis in mice. Journal of Orthopaedic Research®, 41(4), 884-890.

Janusz, P., Tokłowicz, M., Andrusiewicz, M., Kotwicka, M., & Kotwicki, T. (2022). Association of LBX1 Gene Methylation Level with Disease Severity in Patients with Idiopathic Scoliosis: Study on Deep Paravertebral Muscles. Genes, 13(9), 1556.

Schinzel, F., Seyfer, H., Ebbers, L., & Nothwang, H. G. (2021). The Lbx1 lineage differentially contributes to inhibitory cell types of the dorsal cochlear nucleus, a cerebellum‐like structure, and the cerebellum. Journal of Comparative Neurology, 529(11), 3032-3045.

Sircombe, K. J. (2019). The role of Lbx1 expression in a mouse model of Adolescent Idiopathic Scoliosis (Doctoral dissertation, University of Otago).

Jennings, W., Hou, M., Perterson, D., Missiuna, P., Thabane, L., Tarnopolsky, M., & Samaan, M. C. (2019). Paraspinal muscle ladybird homeobox 1 (LBX1) in adolescent idiopathic scoliosis: A cross-sectional study. The Spine Journal, 19(12), 1911-1916.

Jiang, H., Yang, Q., Liu, Y., Guan, Y., Zhan, X., Xiao, Z., & Wei, Q. (2019). Association between ladybird homeobox 1 gene polymorphisms and adolescent idiopathic scoliosis: A MOOSE-compliant meta-analysis. Medicine, 98(27), e16314.

Nada, D., Julien, C., Samuels, M. E., & Moreau, A. (2018). A Replication Study for Association of LBX1 Locus With Adolescent Idiopathic Scoliosis in French–Canadian Population. Spine, 43(3), 172-178.

Nikolova, S., Dikova, M., Dikov, D., Djerov, A., Savov, A., Kremensky, I., & Loukanov, A. (2018). Positive association between the progression of idiopathic scoliosis and the common variant near the LBX1 gene in Southeast European population. Journal of Applied Biomedicine, 16(4), 344-349.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

LBX1 Matched Antibody Pair (681) (CAT#: APMAB-681LY)

Related Products

LBX1 Matched Antibody Pair (681) (CAT#: APMAB-681LY)

Mouse Anti-LBX1 Recombinant Antibody (CBYJL-1239) (CAT#: CBMAB-L0773-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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