Mouse Anti-LCN2 Recombinant Antibody (A1352) (CBMAB-AP5063LY)

Name: Mouse Anti-LCN2 Recombinant Antibody (A1352)
SKU: CBMAB-AP5063LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

A1352

Application

ICC, IHC, IP, WB

Immunogen

RPB388Hu01-Recombinant Neutrophil Gelatinase Associated Lipocalin (NGAL)

Specificity

Human

Antibody Isotype

IgG2b, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

Affinity purity

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Lipocalin-2

Entrez Gene ID

3934

UniProt ID

P80188

Alternative Names

LCN2, p25, Lipocalin 2, Oncogene 24p3, 25 kDa alpha-2-microglobulin-related subunit of MMP-9, Siderocalin LCN2

Function

MAB388Hu21

Biological Process

Apoptotic processIEA:UniProtKB-KW
Defense response to bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Innate immune responseISS:UniProtKB
Positive regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Sequestering of iron ionManual Assertion Based On ExperimentIDA:UniProtKB
Siderophore transportISS:UniProtKB

Cellular Location

Secreted
Cytoplasmic granule lumen
Cytoplasmic vesicle lumen
Upon binding to the SLC22A17 (24p3R) receptor, it is internalized (By similarity).
Releases the bound iron in the acidic lumen of cytoplasmic vesicles (PubMed:12453413, PubMed:20581821).

Schröder, S. K., Gasterich, N., Weiskirchen, S., & Weiskirchen, R. (2023). Lipocalin 2 receptors: Facts, fictions, and myths. Frontiers in Immunology, 14.

Al Jaberi, S., Cohen, A., D’Souza, C., Abdulrazzaq, Y. M., Ojha, S., Bastaki, S., & Adeghate, E. A. (2021). Lipocalin-2: Structure, function, distribution and role in metabolic disorders. Biomedicine & Pharmacotherapy, 142, 112002.

Dekens, D. W., Eisel, U. L., Gouweleeuw, L., Schoemaker, R. G., De Deyn, P. P., & Naudé, P. J. (2021). Lipocalin 2 as a link between ageing, risk factor conditions and age-related brain diseases. Ageing Research Reviews, 70, 101414.

Petropoulou, P. I., Mosialou, I., Shikhel, S., Hao, L., Panitsas, K., Bisikirska, B., ... & Kousteni, S. (2020). Lipocalin-2 is an anorexigenic signal in primates. Elife, 9, e58949.

Santiago-Sánchez, G. S., Pita-Grisanti, V., Quiñones-Díaz, B., Gumpper, K., Cruz-Monserrate, Z., & Vivas-Mejía, P. E. (2020). Biological functions and therapeutic potential of lipocalin 2 in cancer. International journal of molecular sciences, 21(12), 4365.

Mosialou, I., Shikhel, S., Luo, N., Petropoulou, P. I., Panitsas, K., Bisikirska, B., ... & Kousteni, S. (2020). Lipocalin-2 counteracts metabolic dysregulation in obesity and diabetes. Journal of Experimental Medicine, 217(10), e20191261.

Bhusal, A., Rahman, M. H., Lee, W. H., Bae, Y. C., Lee, I. K., & Suk, K. (2019). Paradoxical role of lipocalin-2 in metabolic disorders and neurological complications. Biochemical Pharmacology, 169, 113626.

Hu, C., Yang, K., Li, M., Huang, W., Zhang, F., & Wang, H. (2018). Lipocalin 2: a potential therapeutic target for breast cancer metastasis. OncoTargets and therapy, 8099-8106.

Song, J., & Kim, O. Y. (2018). Perspectives in Lipocalin-2: emerging biomarker for medical diagnosis and prognosis for Alzheimer's disease. Clinical nutrition research, 7(1), 1-10.

Kang, S. S., Ren, Y., Liu, C. C., Kurti, A., Baker, K. E., Bu, G., ... & Fryer, J. D. (2018). Lipocalin-2 protects the brain during inflammatory conditions. Molecular psychiatry, 23(2), 344-350.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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