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Rabbit Anti-LCN2 Recombinant Antibody (D4M8L) (CBMAB-CP1368-LY)

The product is antibody recognizes LCN2. The antibody D4M8L immunoassay techniques such as: WB.
See all LCN2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
D4M8L
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala73 of human LCN2 protein.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Lipocalin-2
Entrez Gene ID
3934
UniProt ID
P80188
Function
Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development (PubMed:12453413, PubMed:27780864, PubMed:20581821).
Binds iron through association with 2,3-dihydroxybenzoic acid (2,3-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis (By similarity).
Involved in innate immunity; limits bacterial proliferation by sequestering iron bound to microbial siderophores, such as enterobactin (PubMed:27780864).
Can also bind siderophores from M.tuberculosis (PubMed:15642259, PubMed:21978368).
Biological Process
Apoptotic processIEA:UniProtKB-KW
Defense response to bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Innate immune responseISS:UniProtKB
Positive regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Sequestering of iron ionManual Assertion Based On ExperimentIDA:UniProtKB
Siderophore transportISS:UniProtKB
Cellular Location
Secreted
Cytoplasmic granule lumen
Cytoplasmic vesicle lumen
Upon binding to the SLC22A17 (24p3R) receptor, it is internalized (By similarity).
Releases the bound iron in the acidic lumen of cytoplasmic vesicles (PubMed:12453413, PubMed:20581821).

Schröder, S. K., Gasterich, N., Weiskirchen, S., & Weiskirchen, R. (2023). Lipocalin 2 receptors: Facts, fictions, and myths. Frontiers in Immunology, 14.

Al Jaberi, S., Cohen, A., D’Souza, C., Abdulrazzaq, Y. M., Ojha, S., Bastaki, S., & Adeghate, E. A. (2021). Lipocalin-2: Structure, function, distribution and role in metabolic disorders. Biomedicine & Pharmacotherapy, 142, 112002.

Dekens, D. W., Eisel, U. L., Gouweleeuw, L., Schoemaker, R. G., De Deyn, P. P., & Naudé, P. J. (2021). Lipocalin 2 as a link between ageing, risk factor conditions and age-related brain diseases. Ageing Research Reviews, 70, 101414.

Petropoulou, P. I., Mosialou, I., Shikhel, S., Hao, L., Panitsas, K., Bisikirska, B., ... & Kousteni, S. (2020). Lipocalin-2 is an anorexigenic signal in primates. Elife, 9, e58949.

Santiago-Sánchez, G. S., Pita-Grisanti, V., Quiñones-Díaz, B., Gumpper, K., Cruz-Monserrate, Z., & Vivas-Mejía, P. E. (2020). Biological functions and therapeutic potential of lipocalin 2 in cancer. International journal of molecular sciences, 21(12), 4365.

Mosialou, I., Shikhel, S., Luo, N., Petropoulou, P. I., Panitsas, K., Bisikirska, B., ... & Kousteni, S. (2020). Lipocalin-2 counteracts metabolic dysregulation in obesity and diabetes. Journal of Experimental Medicine, 217(10), e20191261.

Bhusal, A., Rahman, M. H., Lee, W. H., Bae, Y. C., Lee, I. K., & Suk, K. (2019). Paradoxical role of lipocalin-2 in metabolic disorders and neurological complications. Biochemical Pharmacology, 169, 113626.

Hu, C., Yang, K., Li, M., Huang, W., Zhang, F., & Wang, H. (2018). Lipocalin 2: a potential therapeutic target for breast cancer metastasis. OncoTargets and therapy, 8099-8106.

Song, J., & Kim, O. Y. (2018). Perspectives in Lipocalin-2: emerging biomarker for medical diagnosis and prognosis for Alzheimer's disease. Clinical nutrition research, 7(1), 1-10.

Kang, S. S., Ren, Y., Liu, C. C., Kurti, A., Baker, K. E., Bu, G., ... & Fryer, J. D. (2018). Lipocalin-2 protects the brain during inflammatory conditions. Molecular psychiatry, 23(2), 344-350.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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