Mouse Anti-LCP2 Recombinant Antibody (CBXS-0040) (CBMAB-S3041-CQ)

Name: Mouse Anti-LCP2 Recombinant Antibody (CBXS-0040)
SKU: CBMAB-S3041-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXS-0040

Application

WB, IHC-P

Specificity

Human, Mouse, Pig

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

15 mM sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

LCP2

Introduction

SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.

Entrez Gene ID

Human	3937
Mouse	16822
Pig	100511843

UniProt ID

Human	Q13094
Mouse	Q60787
Pig	F1RRX4

Alternative Names

SLP76; SLP-76

Function

Involved in T-cell antigen receptor mediated signaling.

Biological Process

Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Mast cell activationIEA:Ensembl
Positive regulation of protein kinase activityManual Assertion Based On ExperimentIEP:CACAO
T cell receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm

PTM

Phosphorylated after T-cell receptor activation by ZAP70, ITK and TXK, which leads to the up-regulation of Th1 preferred cytokine IL-2. SYK-dependent phosphorylation is required for recruitment of PI3K signaling components.

Li, M., Zhong, X., & Xu, W. (2023). Substance P increases STAT6-mediated transcription activation of LCP2 to sustain M2 macrophage predominance in pediatric asthma. The American Journal of Pathology.

Iyer, V. S., Boddul, S. V., Johnsson, A. K., Raposo, B., Sharma, R. K., Shen, Y., ... & Wermeling, F. (2022). Modulating T-cell activation with antisense oligonucleotides targeting lymphocyte cytosolic protein 2. Journal of Autoimmunity, 131, 102857.

Huo, Y., Zhang, K., Han, S., Feng, Y., & Bao, Y. (2021). Lymphocyte cytosolic protein 2 is a novel prognostic marker in lung adenocarcinoma. Journal of International Medical Research, 49(11), 03000605211059681.

Wang, Z., & Peng, M. (2021). A novel prognostic biomarker LCP2 correlates with metastatic melanoma-infiltrating CD8+ T cells. Scientific reports, 11(1), 9164.

Yu, Y. L., Chen, M., Zhu, H., Zhuo, M. X., Chen, P., Mao, Y. J., ... & Ye, M. (2021). STAT1 epigenetically regulates LCP2 and TNFAIP2 by recruiting EP300 to contribute to the pathogenesis of inflammatory bowel disease. Clinical Epigenetics, 13(1), 127.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

LCP2 Matched Antibody Pair (683) (CAT#: APMAB-683LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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