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LCP2

LCP2 is an adapter protein that acts as a substrate of the T cell antigen receptor (TCR)-activated protein tyrosine kinase pathway. The encoded protein associates with growth factor receptor bound protein 2, and is thought to play a role TCR-mediated intracellular signal transduction. A similar protein in mouse plays a role in normal T-cell development and activation.

Full Name

LCP2

Function

Involved in T-cell antigen receptor mediated signaling.

Biological Process

Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Mast cell activationIEA:Ensembl
Positive regulation of protein kinase activityManual Assertion Based On ExperimentIEP:CACAO
T cell receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm

PTM

Phosphorylated after T-cell receptor activation by ZAP70, ITK and TXK, which leads to the up-regulation of Th1 preferred cytokine IL-2. SYK-dependent phosphorylation is required for recruitment of PI3K signaling components.

Anti-LCP2 antibodies

Mouse Anti-LCP2 Recombinant Antibody (CBYCL-176) (CBMAB-L0077-YC)

SDS

Target: LCP2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYCL-176

Application*: IP, WB

Mouse Anti-LCP2 Recombinant Antibody (CBYCL-175) (CBMAB-L0076-YC)

SDS

Target: LCP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYCL-175

Application*: WB

Mouse Anti-LCP2 Recombinant Antibody (CBXS-3333) (CBMAB-S6070-CQ)

SDS

Target: LCP2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse, Pig

Clone: CBXS-3333

Application*: IH, WB

Mouse Anti-LCP2 Recombinant Antibody (CBXS-1936) (CBMAB-S4718-CQ)

SDS

Target: LCP2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXS-1936

Application*: WB, IC

Rabbit Anti-LCP2 Recombinant Antibody (CBXS-1465) (CBMAB-S4321-CQ)

SDS

Target: LCP2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Rabbit, Human

Clone: CBXS-1465

Application*: WB, F

Rabbit Anti-LCP2 Recombinant Antibody (CBXS-1458) (CBMAB-S4314-CQ)

SDS

Target: LCP2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBXS-1458

Application*: WB, P, IC

Rabbit Anti-LCP2 Recombinant Antibody (CBXS-1196) (CBMAB-S4062-CQ)

SDS

Target: LCP2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBXS-1196

Application*: WB, IC, F

Mouse Anti-LCP2 Recombinant Antibody (CBXS-0040) (CBMAB-S3041-CQ)

SDS

Target: LCP2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse, Pig

Clone: CBXS-0040

Application*: WB, P

Rabbit Anti-LCP2 Recombinant Antibody (CBXS-0038) (CBMAB-S3040-CQ)

SDS

Target: LCP2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBXS-0038

Application*: WB, IP, P, IF, F

Human Anti-LCP2 Recombinant Antibody (CBXS-3563) (CBMAB-S0396-CQ)

SDS

Target: LCP2

Host: Human

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-3563

Application*: F

Mouse Anti-LCP2 Recombinant Antibody (SLP-76/03) (CBMAB-S0368-CQ)

SDS

Target: LCP2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse, Pig

Clone: SLP-76/03

Application*: WB, IH, P

Mouse Anti-LCP2 Recombinant Antibody (SLP-76-03) (CBMAB-L0903-YJ)

SDS

Target: LCP2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Pig, Mouse

Clone: SLP-76-03

Application*: P, WB

Mouse Anti-LCP2 Recombinant Antibody (H76) (CBMAB-L0902-YJ)

SDS

Target: LCP2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse

Clone: H76

Application*: F

Mouse Anti-LCP2 Recombinant Antibody (AS55) (CBMAB-L0901-YJ)

SDS

Target: LCP2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: AS55

Application*: IP, WB

Mouse Anti-LCP2 Recombinant Antibody (CBYJL-1317) (CBMAB-L0899-YJ)

SDS

Target: LCP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJL-1317

Application*: WB

Mouse Anti-LCP2 Recombinant Antibody (CBYJL-1316) (CBMAB-L0898-YJ)

SDS

Target: LCP2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYJL-1316

Application*: IH, WB

Rabbit Anti-LCP2 Recombinant Antibody (D1R1A) (CBMAB-CP2483-LY)

SDS

Target: LCP2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: D1R1A

Application*: WB, IP, P, IF (IC), F

Rabbit Anti-LCP2 Recombinant Antibody (E4N7E) (CBMAB-CP2482-LY)

SDS

Target: LCP2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: E4N7E

Application*: WB, IP

Rabbit Anti-LCP2 (Phosphorylated S376) Recombinant Antibody (D9D6E) (PTM-CBMAB-0152LY)

SDS

Target: LCP2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: D9D6E

Application*: WB

Rabbit Anti-LCP2 (Phosphorylated S376) Recombinant Antibody (D7S1K) (PTM-CBMAB-0145LY)

SDS

Target: LCP2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: D7S1K

Application*: FC

LCP2 Matched Antibody Pair (683) (APMAB-683LY)

SDS

Target: LCP2

Specificity: Human

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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