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Mouse Anti-LDAH Recombinant Antibody (CBWJC-4120) (CBMAB-C5464WJ)

This product is a Mouse antibody that recognizes LDAH. This antibody CBWJC-4120 can be used for immunoassay techniques such as: WB, FC.
See all LDAH antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJC-4120
Antibody Isotype
IgG1
Application
WB, FC

Basic Information

Immunogen
Full length human recombinant protein of human C2orf43(NP_068744) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS (PH 7.3), 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Lipid Droplet Associated Hydrolase
Introduction
LDAH (Lipid Droplet Associated Hydrolase) is a Protein Coding gene. Diseases associated with LDAH include Defective Apolipoprotein B-100.
Entrez Gene ID
60526
UniProt ID
Q9H6V9
Alternative Names
hLDAH; C2orf43
Function
Probable serine lipid hydrolase associated with lipid droplets. Appears to lack cholesterol esterase activity. Appears to lack triglyceride lipase activity. Highly expressed in macrophage-rich areas in atherosclerotic lesions, suggesting that it could promote cholesterol ester turnover in macrophages.
Biological Process
Lipid catabolic processIEA:UniProtKB-KW
Lipid storageManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Lipid droplet
Endoplasmic reticulum
Localizes to the endoplasmic reticulum in absence of lipid droplets and translocates to lipid droplets upon lipid storage induction.

Bai, R., Rebelo, A., Kleeff, J., & Sunami, Y. (2021). Identification of prognostic lipid droplet-associated genes in pancreatic cancer patients via bioinformatics analysis. Lipids in Health and Disease, 20(1), 1-12.

Robichaud, S., Fairman, G., Vijithakumar, V., Mak, E., Cook, D. P., Pelletier, A. R., ... & Ouimet, M. (2021). Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells. Autophagy, 17(11), 3671-3689.

Dubey, R., Stivala, C. E., Nguyen, H. Q., Goo, Y. H., Paul, A., Carette, J. E., ... & Rohatgi, R. (2020). Lipid droplets can promote drug accumulation and activation. Nature chemical biology, 16(2), 206-213.

Werthebach, M., Stewart, F. A., Gahlen, A., Mettler-Altmann, T., Akhtar, I., Maas-Enriquez, K., ... & Beller, M. (2019). Control of Drosophila growth and survival by the lipid droplet-associated protein CG9186/Sturkopf. Cell reports, 26(13), 3726-3740.

VBSC, T. (2018). Saccharomyces cerevisiae lipid droplet associated enzyme Ypr147cp shows both TAG lipase and ester hydrolase activities. The Journal of General and Applied Microbiology, 64(2), 76-83.

Goo, Y. H., Lee, I., Lydic, T. A., Bangru, S., Saha, P., Kalsotra, A., ... & Paul, A. (2018). Lipid Droplet Associated Hydrolase (LDAH) Impacts Oxysterol Metabolism and Prevents Atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 38(Suppl_1), A447-A447.

Currall, B. B., Chen, M., Sallari, R. C., Cotter, M., Wong, K. E., Robertson, N. G., ... & Morton, C. C. (2018). Loss of LDAH associated with prostate cancer and hearing loss. Human molecular genetics, 27(24), 4194-4203.

Inloes, J. M., Kiosses, W. B., Wang, H., Walther, T. C., Farese Jr, R. V., & Cravatt, B. F. (2018). Functional contribution of the spastic paraplegia-related triglyceride hydrolase DDHD2 to the formation and content of lipid droplets. Biochemistry, 57(5), 827-838.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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