Mouse Anti-LDAH Recombinant Antibody (CBYJL-1328) (CBMAB-L0913-YJ)

Name: Mouse Anti-LDAH Recombinant Antibody (CBYJL-1328)
SKU: CBMAB-L0913-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYJL-1328

Application

FC, WB

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.3, 1% BSA, 50% Glycerol

Preservative

0.02% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Lipid Droplet Associated Hydrolase

Introduction

Diseases associated with LDAH (Lipid Droplet Associated Hydrolase) include Defective Apolipoprotein B-100.Serine lipid hydrolase associated with lipid droplets. Highly expressed in macrophage-rich areas in atherosclerotic lesions, suggesting that it could promote cholesterol ester turnover in macrophages.

Entrez Gene ID

60526

UniProt ID

Q9H6V9

Alternative Names

C2orf43; hLDAH

Function

Probable serine lipid hydrolase associated with lipid droplets. Appears to lack cholesterol esterase activity. Appears to lack triglyceride lipase activity. Highly expressed in macrophage-rich areas in atherosclerotic lesions, suggesting that it could promote cholesterol ester turnover in macrophages.

Biological Process

Lipid catabolic processIEA:UniProtKB-KW
Lipid storageManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Lipid droplet
Endoplasmic reticulum
Localizes to the endoplasmic reticulum in absence of lipid droplets and translocates to lipid droplets upon lipid storage induction.

Bai, R., Rebelo, A., Kleeff, J., & Sunami, Y. (2021). Identification of prognostic lipid droplet-associated genes in pancreatic cancer patients via bioinformatics analysis. Lipids in Health and Disease, 20(1), 1-12.

Robichaud, S., Fairman, G., Vijithakumar, V., Mak, E., Cook, D. P., Pelletier, A. R., ... & Ouimet, M. (2021). Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells. Autophagy, 17(11), 3671-3689.

Dubey, R., Stivala, C. E., Nguyen, H. Q., Goo, Y. H., Paul, A., Carette, J. E., ... & Rohatgi, R. (2020). Lipid droplets can promote drug accumulation and activation. Nature chemical biology, 16(2), 206-213.

Werthebach, M., Stewart, F. A., Gahlen, A., Mettler-Altmann, T., Akhtar, I., Maas-Enriquez, K., ... & Beller, M. (2019). Control of Drosophila growth and survival by the lipid droplet-associated protein CG9186/Sturkopf. Cell reports, 26(13), 3726-3740.

VBSC, T. (2018). Saccharomyces cerevisiae lipid droplet associated enzyme Ypr147cp shows both TAG lipase and ester hydrolase activities. The Journal of General and Applied Microbiology, 64(2), 76-83.

Goo, Y. H., Lee, I., Lydic, T. A., Bangru, S., Saha, P., Kalsotra, A., ... & Paul, A. (2018). Lipid Droplet Associated Hydrolase (LDAH) Impacts Oxysterol Metabolism and Prevents Atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 38(Suppl_1), A447-A447.

Currall, B. B., Chen, M., Sallari, R. C., Cotter, M., Wong, K. E., Robertson, N. G., ... & Morton, C. C. (2018). Loss of LDAH associated with prostate cancer and hearing loss. Human molecular genetics, 27(24), 4194-4203.

Inloes, J. M., Kiosses, W. B., Wang, H., Walther, T. C., Farese Jr, R. V., & Cravatt, B. F. (2018). Functional contribution of the spastic paraplegia-related triglyceride hydrolase DDHD2 to the formation and content of lipid droplets. Biochemistry, 57(5), 827-838.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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