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Mouse Anti-LDHA Recombinant Antibody (CBYJL-1349) (CBMAB-L0951-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Lactate Dehydrogenase A (LDHA). The antibody can be used for immunoassay techniques, such as IHC-P.
See all LDHA antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJL-1349
Antibody Isotype
IgG2b
Application
IHC-P

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
LDHA
Introduction
LDHA catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. LDHA is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been observed for this gene. The human genome contains several non-transcribed pseudogenes of this gene.
Entrez Gene ID
UniProt ID
Alternative Names
GSD11; HEL-S-133P; LDHM; PIG19
Biological Process
Glycolytic process1 PublicationNAS:UniProtKB
Lactate metabolic processManual Assertion Based On ExperimentIDA:ComplexPortal
Pyruvate metabolic processManual Assertion Based On ExperimentIDA:ComplexPortal
Substantia nigra developmentHEP:UniProtKB
Cellular Location
Cytoplasm
Involvement in disease
Glycogen storage disease 11 (GSD11):
A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.
PTM
ISGylated.

Ban, E. J., Kim, D., Kim, J. K., Kang, S. W., Lee, J., Jeong, J. J., ... & Kim, K. (2021). Lactate dehydrogenase A as a potential new biomarker for thyroid cancer. Endocrinology and Metabolism, 36(1), 96-105.

Dai, C., Li, Q., May, H. I., Li, C., Zhang, G., Sharma, G., ... & Wang, Z. V. (2020). Lactate dehydrogenase A governs cardiac hypertrophic growth in response to hemodynamic stress. Cell reports, 32(9).

Yu, H., Yin, Y., Yi, Y., Cheng, Z., Kuang, W., Li, R., ... & Zhang, G. (2020). Targeting lactate dehydrogenase A (LDHA) exerts antileukemic effects on T‐cell acute lymphoblastic leukemia. Cancer Communications, 40(10), 501-517.

Hong, M., Zhang, X. B., Xiang, F., Fei, X., Ouyang, X. L., & Peng, X. C. (2020). MiR-34a suppresses osteoblast differentiation through glycolysis inhibition by targeting lactate dehydrogenase-A (LDHA). In Vitro Cellular & Developmental Biology-Animal, 56, 480-487.

Woodford, M. R., Chen, V. Z., Backe, S. J., Bratslavsky, G., & Mollapour, M. (2019). Structural and functional regulation of lactate dehydrogenase-A in cancer. Future Medicinal Chemistry, 12(5), 439-455.

Jafary, F., Ganjalikhany, M. R., Moradi, A., Hemati, M., & Jafari, S. (2019). Novel peptide inhibitors for lactate dehydrogenase A (LDHA): a survey to inhibit LDHA activity via disruption of protein-protein interaction. Scientific reports, 9(1), 4686.

Feng, Y., Xiong, Y., Qiao, T., Li, X., Jia, L., & Han, Y. (2018). Lactate dehydrogenase A: A key player in carcinogenesis and potential target in cancer therapy. Cancer medicine, 7(12), 6124-6136.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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