Mouse Anti-LDOC1 Recombinant Antibody (2507C1a) (CBMAB-L1028-YJ)

Name: Mouse Anti-LDOC1 Recombinant Antibody (2507C1a)
SKU: CBMAB-L1028-YJ
Rating: 5 (1 reviews)

See all LDOC1 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2507C1a

Application

Dot

Immunogen

LDOC1 antibody was raised in mouse using recombinant Human Leucine Zipper, Down-Regulated In Cancer 1 (Ldoc1).

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4, 1% BSA

Preservative

0.05% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

leucine zipper, down-regulated in cancer 1

Introduction

LDOC1 contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. LDOC1 localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers.

Entrez Gene ID

23641

UniProt ID

O95751

Alternative Names

BCUR1; Mar7; Mart7; RTL7; SIRH7

Function

May have an important role in the development and/or progression of some cancers.

Biological Process

Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIMP:UniProtKB
Cellular response to muramyl dipeptideManual Assertion Based On ExperimentIMP:UniProtKB
Maternal placenta developmentIEA:Ensembl
Maternal process involved in parturitionIEA:Ensembl
Negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Regulation of growth hormone activityIEA:Ensembl

Cellular Location

Nucleus

Li, C. C., Lu, C. Y., Hsu, C. H., Hsieh, D. J. Y., Wang, T. F., Ho, T. J., ... & Huang, C. Y. (2023). Calycosin inhibits gemcitabine-resistant lung cancer cells proliferation through modulation of the LDOC1/GNL3L/NFκB. Journal of Physiology Investigation, 66(4), 189-199.

Lee, C. H., Hung, P. F., Liu, K. J., Chung, H. L., Yang, W. C., Hsu, K. C., ... & Yen, C. Y. (2020). LDOC1 suppresses microbe-induced production of il-1β in human normal and cancerous oral cells through the PI3K/AKT/GSK-3β axis. Cancers, 12(11), 3148.

Wanka, G., Schmoeckel, E., Mayr, D., Fuerst, S., Kuhn, C., Mahner, S., ... & Jueckstock, J. (2020). LDOC1 as negative prognostic marker for vulvar cancer patients. International Journal of Molecular Sciences, 21(23), 9287.

Zhao, S., Zhao, Y., Wang, Q., Li, Z., Ma, X., Wu, L., ... & Qin, G. (2020). LDOC1 is differentially expressed in thyroid cancer and display tumor‐suppressive function in papillary thyroid carcinoma. Cell Biology International, 44(4), 985-997.

Jiang, J., Li, Y., & Jiang, Z. (2019). Effects of LDOC1 on colorectal cancer cells via downregulation of the Wnt/β-catenin signaling pathway. Oncology Reports, 41(6), 3281-3291.

Lee, C. H., Yang, J. R., Chen, C. Y., Tsai, M. H., Hung, P. F., Chen, S. J., ... & Lin, P. (2019). Novel STAT3 inhibitor LDOC1 targets phospho-JAK2 for degradation by interacting with LNX1 and regulates the aggressiveness of lung cancer. Cancers, 11(1), 63.

Chen, S., & Wang, J. (2019). HAND2-AS1 inhibits invasion and metastasis of cervical cancer cells via microRNA-330-5p-mediated LDOC1. Cancer cell international, 19, 1-16.

Liu, C. J., Chen, J. H., Hsia, S. M., Liao, C. C., Chang, H. W., Shieh, T. M., & Shih, Y. H. (2019). Salivary LDOC1 is a gender-difference biomarker of oral squamous cell carcinoma. PeerJ, 7, e6732.

Zhao, C., Du, F., Zhao, Y., Wang, S., & Qi, L. (2019). Acute myeloid leukemia cells secrete microRNA-4532-containing exosomes to mediate normal hematopoiesis in hematopoietic stem cells by activating the LDOC1-dependent STAT3 signaling pathway. Stem Cell Research & Therapy, 10(1), 1-12.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-LDOC1 Recombinant Antibody (2507C1a)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-LDOC1 Recombinant Antibody (CBYJL-2607) (CAT#: CBMAB-L1027-YJ)

Mouse Anti-LDOC1 Recombinant Antibody (8C209) (CAT#: CBMAB-L1030-YJ)

Mouse Anti-LDOC1 Recombinant Antibody (CBYJL-1385) (CAT#: CBMAB-L1029-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry