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Mouse Anti-LDOC1 Recombinant Antibody (CBYJL-2607) (CBMAB-L1027-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJL-2607
Antibody Isotype
IgG1
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
leucine zipper, down-regulated in cancer 1
Introduction
LDOC1 contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. LDOC1 localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers.
Entrez Gene ID
23641
UniProt ID
O95751
Alternative Names
BCUR1; Mar7; Mart7; RTL7; SIRH7
Function
May have an important role in the development and/or progression of some cancers.
Biological Process
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIMP:UniProtKB
Cellular response to muramyl dipeptideManual Assertion Based On ExperimentIMP:UniProtKB
Maternal placenta developmentIEA:Ensembl
Maternal process involved in parturitionIEA:Ensembl
Negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Regulation of growth hormone activityIEA:Ensembl
Cellular Location
Nucleus
More Infomation

Li, C. C., Lu, C. Y., Hsu, C. H., Hsieh, D. J. Y., Wang, T. F., Ho, T. J., ... & Huang, C. Y. (2023). Calycosin inhibits gemcitabine-resistant lung cancer cells proliferation through modulation of the LDOC1/GNL3L/NFκB. Journal of Physiology Investigation, 66(4), 189-199.

Lee, C. H., Hung, P. F., Liu, K. J., Chung, H. L., Yang, W. C., Hsu, K. C., ... & Yen, C. Y. (2020). LDOC1 suppresses microbe-induced production of il-1β in human normal and cancerous oral cells through the PI3K/AKT/GSK-3β axis. Cancers, 12(11), 3148.

Wanka, G., Schmoeckel, E., Mayr, D., Fuerst, S., Kuhn, C., Mahner, S., ... & Jueckstock, J. (2020). LDOC1 as negative prognostic marker for vulvar cancer patients. International Journal of Molecular Sciences, 21(23), 9287.

Zhao, S., Zhao, Y., Wang, Q., Li, Z., Ma, X., Wu, L., ... & Qin, G. (2020). LDOC1 is differentially expressed in thyroid cancer and display tumor‐suppressive function in papillary thyroid carcinoma. Cell Biology International, 44(4), 985-997.

Jiang, J., Li, Y., & Jiang, Z. (2019). Effects of LDOC1 on colorectal cancer cells via downregulation of the Wnt/β-catenin signaling pathway. Oncology Reports, 41(6), 3281-3291.

Lee, C. H., Yang, J. R., Chen, C. Y., Tsai, M. H., Hung, P. F., Chen, S. J., ... & Lin, P. (2019). Novel STAT3 inhibitor LDOC1 targets phospho-JAK2 for degradation by interacting with LNX1 and regulates the aggressiveness of lung cancer. Cancers, 11(1), 63.

Chen, S., & Wang, J. (2019). HAND2-AS1 inhibits invasion and metastasis of cervical cancer cells via microRNA-330-5p-mediated LDOC1. Cancer cell international, 19, 1-16.

Liu, C. J., Chen, J. H., Hsia, S. M., Liao, C. C., Chang, H. W., Shieh, T. M., & Shih, Y. H. (2019). Salivary LDOC1 is a gender-difference biomarker of oral squamous cell carcinoma. PeerJ, 7, e6732.

Zhao, C., Du, F., Zhao, Y., Wang, S., & Qi, L. (2019). Acute myeloid leukemia cells secrete microRNA-4532-containing exosomes to mediate normal hematopoiesis in hematopoietic stem cells by activating the LDOC1-dependent STAT3 signaling pathway. Stem Cell Research & Therapy, 10(1), 1-12.

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For research use only. Not intended for any clinical use.

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