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Mouse Anti-LECT2 Recombinant Antibody (5C5) (CBMAB-L1036-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
5C5
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
Recombinant full-length human LECT2 purified from culture supernatant of stable CHO transfectant cells.
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Leukocyte Cell Derived Chemotaxin 2
Introduction
LECT2 is a secreted, 16 kDa protein that acts as a chemotactic factor to neutrophils and stimulates the growth of chondrocytes and osteoblasts. This protein has high sequence similarity to the chondromodulin repeat regions of the chicken myb-induced myeloid 1 protein. A polymorphism in this gene may be associated with rheumatoid arthritis. Among its related pathways are C-MYB transcription factor network. Gene Ontology (GO) annotations related to this gene include identical protein binding. Has a neutrophil chemotactic activity. Also a positive regulator of chondrocyte proliferation. Does not show metalloendopeptidase activity.
Entrez Gene ID
3950
UniProt ID
O14960
Alternative Names
chm-II; chm2
Function
Has a neutrophil chemotactic activity. Also a positive regulator of chondrocyte proliferation (PubMed:9524238).
Does not show metalloendopeptidase activity (PubMed:27334921).
Biological Process
ChemotaxisManual Assertion Based On ExperimentTAS:ProtInc
Skeletal system developmentManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm
Secreted
More Infomation

Hu, Y. Z., Ma, Z. Y., Wu, C. S., Wang, J., Zhang, Y. A., & Zhang, X. J. (2022). LECT2 is a novel antibacterial protein in vertebrates. The Journal of Immunology, 208(8), 2037-2053.

Zhu, S., Bennett, S., Li, Y., Liu, M., & Xu, J. (2022). The molecular structure and role of LECT2 or CHM‐II in arthritis, cancer, and other diseases. Journal of Cellular Physiology, 237(1), 480-488.

Xie, Y., Fan, K. W., Guan, S. X., Hu, Y., Gao, Y., & Zhou, W. J. (2022). LECT2: A pleiotropic and promising hepatokine, from bench to bedside. Journal of Cellular and Molecular Medicine, 26(13), 3598-3607.

Mann, B. K., Bhandohal, J. S., Cobos, E., Chitturi, C., & Eppanapally, S. (2022). LECT-2 amyloidosis: what do we know?. Journal of Investigative Medicine, 70(2), 348-353.

Kim, J., Lee, S. K., Kim, D., Lee, E., Park, C. Y., Choe, H., ... & Jang, Y. J. (2022). Adipose tissue LECT2 expression is associated with obesity and insulin resistance in K orean women. Obesity, 30(7), 1430-1441.

Li, Q., Zhang, Z., Fan, W., Huang, Y., Niu, J., Luo, G., ... & Jian, J. (2021). LECT2 protects Nile tilapia (Oreochromis niloticus) against Streptococcus agalatiae infection. Frontiers in Immunology, 12, 667781.

Takata, N., Ishii, K. A., Takayama, H., Nagashimada, M., Kamoshita, K., Tanaka, T., ... & Takamura, T. (2021). LECT2 as a hepatokine links liver steatosis to inflammation via activating tissue macrophages in NASH. Scientific Reports, 11(1), 555.

Xu, M., Xu, H. H., Lin, Y., Sun, X., Wang, L. J., Fang, Z. P., ... & Zhou, W. J. (2019). LECT2, a ligand for Tie1, plays a crucial role in liver fibrogenesis. Cell, 178(6), 1478-1492.

L’hermitte, A., Pham, S., Cadoux, M., Couchy, G., Caruso, S., Anson, M., ... & Couty, J. P. (2019). Lect2 controls inflammatory monocytes to constrain the growth and progression of hepatocellular carcinoma. Hepatology, 69(1), 160-178.

Jung, T. W., Chung, Y. H., Kim, H. C., Abd El-Aty, A. M., & Jeong, J. H. (2018). LECT2 promotes inflammation and insulin resistance in adipocytes via P38 pathways. Journal of Molecular Endocrinology, 61(1), 37-45.

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For research use only. Not intended for any clinical use.

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