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Mouse Anti-LETM1 Recombinant Antibody (CBYCL-241) (CBMAB-L0142-YC)

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Basic Information

Host Animal
Mouse
Clone
CBYCL-241
Application
WB, IHC-P, FC, ICC, IF
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
leucine zipper and EF-hand containing transmembrane protein 1
Introduction
LETM1 is a protein that is localized to the inner mitochondrial membrane. The protein functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphology and cellular viability. Mutations in this gene cause Wolf-Hirschhorn syndrome, a complex malformation syndrome caused by the deletion of parts of the distal short arm of chromosome 4.
Entrez Gene ID
3954
UniProt ID
O95202
Alternative Names
LETM 1; LETM1 and EF hand domain containing protein 1; mitochondrial; LETM1 and EF-hand domain-containing protein 1; Letm1; LETM1_HUMAN; Leucine zipper EF hand containing transmembrane protein 1; Leucine zipper-EF-hand-containing transmembrane protein 1; Mdm38 homolog; mitochondrial; ZNF300 bs-0628R
Function
Mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion (PubMed:19797662).
Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (PubMed:18628306).
Required for the maintenance of the tubular shape and cristae organization (PubMed:18628306).
In contrast to SLC8B1/NCLX, does not constitute the major factor for mitochondrial calcium extrusion (PubMed:24898248).
Biological Process
Calcium export from the mitochondrionManual Assertion Based On ExperimentIDA:UniProtKB
Cellular metal ion homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Cristae formationManual Assertion Based On ExperimentIMP:UniProtKB
Mitochondrial calcium ion homeostasisManual Assertion Based On ExperimentIDA:UniProtKB
Mitochondrial calcium ion transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of mitochondrial calcium ion concentrationManual Assertion Based On ExperimentIMP:UniProtKB
Protein hexamerizationISS:UniProtKB
Protein homooligomerizationISS:UniProtKB
Regulation of cellular hyperosmotic salinity responseManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Mitochondrion inner membrane
Topology
Mitochondrial intermembrane: 116-208
Helical: 209-229
Mitochondrial matrix: 230-739

Tran, Q., Lee, H., Jung, J. H., Chang, S. H., Shrestha, R., Kong, G., ... & Park, J. (2022). Emerging role of LETM1/GRP78 axis in lung cancer. Cell death & disease, 13(6), 543.

Natarajan, G. K., Mishra, J., Camara, A. K., & Kwok, W. M. (2021). LETM1: a single entity with diverse impact on mitochondrial metabolism and cellular signaling. Frontiers in Physiology, 12, 637852.

Li, H., Piao, L., Xu, D., & Xuan, Y. (2020). LETM1 is a potential biomarker that predicts poor prognosis in gastric adenocarcinoma. Experimental and Molecular Pathology, 112, 104333.

Nakamura, S., Matsui, A., Akabane, S., Tamura, Y., Hatano, A., Miyano, Y., ... & Oka, T. (2020). The mitochondrial inner membrane protein LETM1 modulates cristae organization through its LETM domain. Communications biology, 3(1), 99.

Zhang, Y., Chen, L., Cao, Y., Chen, S., Xu, C., Xing, J., & Zhang, K. (2020). LETM1 promotes gastric cancer cell proliferation, migration, and invasion via the PI3K/Akt signaling pathway. Journal of Gastric Cancer, 20(2), 139.

Li, Y., Tran, Q., Shrestha, R., Piao, L., Park, S., Park, J., & Park, J. (2019). LETM1 is required for mitochondrial homeostasis and cellular viability. Molecular Medicine Reports, 19(5), 3367-3375.

Austin, S., & Nowikovsky, K. (2019). LETM1: essential for mitochondrial biology and cation homeostasis?. Trends in biochemical sciences, 44(8), 648-658.

Piao, L., Yang, Z., Feng, Y., Zhang, C., Cui, C., & Xuan, Y. (2019). LETM1 is a potential biomarker of prognosis in lung non-small cell carcinoma. BMC cancer, 19, 1-9.

Piao, L., Feng, Y., Yang, Z., Qi, W., Li, H., Han, H., & Xuan, Y. (2019). LETM1 is a potential cancer stem-like cell marker and predicts poor prognosis in colorectal adenocarcinoma. Pathology-Research and Practice, 215(7), 152437.

Durigon, R., Mitchell, A. L., Jones, A. W., Manole, A., Mennuni, M., Hirst, E. M., ... & Spinazzola, A. (2018). LETM 1 couples mitochondrial DNA metabolism and nutrient preference. EMBO Molecular Medicine, 10(9), e8550.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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