LETM1

LETM1 is a protein that is localized to the inner mitochondrial membrane. The protein functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphology and cellular viability. Mutations in this gene lead to Wolf-Hirschhorn syndrome, a complex malformation syndrome caused by the deletion of parts of the distal short arm of chromosome 4. Related pseudogenes have been identified on chromosomes 8, 15 and 19.
Full Name
leucine zipper and EF-hand containing transmembrane protein 1
Function
Mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion (PubMed:19797662).
Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (PubMed:18628306).
Required for the maintenance of the tubular shape and cristae organization (PubMed:18628306).
In contrast to SLC8B1/NCLX, does not constitute the major factor for mitochondrial calcium extrusion (PubMed:24898248).
Biological Process
Calcium export from the mitochondrionManual Assertion Based On ExperimentIDA:UniProtKB
Cellular metal ion homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Cristae formationManual Assertion Based On ExperimentIMP:UniProtKB
Mitochondrial calcium ion homeostasisManual Assertion Based On ExperimentIDA:UniProtKB
Mitochondrial calcium ion transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of mitochondrial calcium ion concentrationManual Assertion Based On ExperimentIMP:UniProtKB
Protein hexamerizationISS:UniProtKB
Protein homooligomerizationISS:UniProtKB
Regulation of cellular hyperosmotic salinity responseManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Mitochondrion inner membrane
Topology
Mitochondrial intermembrane: 116-208
Helical: 209-229
Mitochondrial matrix: 230-739
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Anti-LETM1 antibodies

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Mouse Anti-LETM1 Recombinant Antibody (2C6) (CBMAB-A4927-LY)

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Target: LETM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2C6
Application*: WB, E
Datasheet SDS

Mouse Anti-LETM1 Recombinant Antibody (CBYCL-243) (CBMAB-L0144-YC)

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Target: LETM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYCL-243
Application*: E, IC, IH, WB
Datasheet SDS

Mouse Anti-LETM1 Recombinant Antibody (CBYCL-242) (CBMAB-L0143-YC)

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Target: LETM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYCL-242
Application*: WB, E, IP, IF, P
Datasheet SDS

Mouse Anti-LETM1 Recombinant Antibody (CBYCL-241) (CBMAB-L0142-YC)

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Target: LETM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYCL-241
Application*: WB, P, F, IC, IF
Datasheet SDS

Mouse Anti-LETM1 Recombinant Antibody (CBYJL-1468) (CBMAB-L1198-YJ)

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Target: LETM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBYJL-1468
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-LETM1 Recombinant Antibody (CBYJL-1467) (CBMAB-L1197-YJ)

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Target: LETM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1467
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-LETM1 Recombinant Antibody (6F7) (CBMAB-L1196-YJ)

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Target: LETM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 6F7
Application*: E, IF, IH, IP, WB
Datasheet SDS

Mouse Anti-LETM1 Recombinant Antibody (CBYJL-1466) (CBMAB-L1195-YJ)

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Target: LETM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJL-1466
Application*: E, IF, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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