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Rabbit Anti-LFNG Recombinant Antibody (D6V2V) (CBMAB-CP1378-LY)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Clone
D6V2V
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu74 of human Lunatic Fringe protein.
Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Entrez Gene ID
Human3955
Mouse16848
Rat170905
Monkey100428736
UniProt ID
HumanQ8NES3
MouseO09010
RatQ924T4
MonkeyF7GN81
Function
Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (By similarity).
Decreases the binding of JAG1 to NOTCH2 but not that of DLL1 (PubMed:11346656).
Essential mediator of somite segmentation and patterning (By similarity).
Biological Process
Animal organ morphogenesis1 PublicationNAS:UniProtKB
Compartment pattern specificationIEA:Ensembl
Marginal zone B cell differentiationISS:UniProtKB
Negative regulation of Notch signaling pathway involved in somitogenesisISS:UniProtKB
Ovarian follicle developmentIEA:Ensembl
Positive regulation of meiotic cell cycleIEA:Ensembl
Positive regulation of Notch signaling pathwayIEA:Ensembl
Positive regulation of protein bindingIEA:Ensembl
Regulation of Notch signaling pathwayISS:CAFA
Regulation of somitogenesisManual Assertion Based On ExperimentIMP:UniProtKB
SomitogenesisISS:UniProtKB
T cell differentiationISS:UniProtKB
Cellular Location
Golgi apparatus membrane
Involvement in disease
Spondylocostal dysostosis 3, autosomal recessive (SCDO3):
A condition of variable severity associated with vertebral and rib segmentation defects. The main skeletal malformations include fusion of vertebrae, hemivertebrae, fusion of certain ribs, and other rib malformations. Deformity of the chest and spine (severe scoliosis, kyphoscoliosis and lordosis) is a natural consequence of the malformation and leads to a dwarf-like appearance. As the thorax is small, infants frequently have respiratory insufficiency and repeated respiratory infections resulting in life-threatening complications in the first year of life.
Topology
Cytoplasmic: 1-8
Helical: 9-29
Lumenal: 30-379
PTM
A soluble form may be derived from the membrane form by proteolytic processing.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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