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Mouse Anti-RXFP1 Recombinant Antibody (3E3) (CBMAB-A4946-LY)

The product is antibody recognizes LGR7. The antibody 3E3 immunoassay techniques such as: WB, ELISA.
See all RXFP1 antibodies
Published Data
Fig.1 Localization of RXFP1 protein in rat small renal arteries by immunohistochemistry.
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Fig.2 Localization of RXFP1 protein in rat small renal arteries by immunohistochemistry immunofluorescence.
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Fig.3 A reduction in cell density was detected in siRXFP1–CNNP-treated tumors.
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Fig.4 Representative sections of siRNA–CNNP-treated tumors stained with anti-RXFP1 monoclonal antibody showing a significant reduction in RXFP1 expression in siRXFP1–CNNP-treated xenografts.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
3E3
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
LGR7 (NP_067647, 68 a.a. ~ 162 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Relaxin/Insulin Like Family Peptide Receptor 1
Entrez Gene ID
59350
UniProt ID
Q9HBX9
Alternative Names
LGR7; LGR7.1; LGR7.10; LGR7.2; MGC138347; MGC142177; RXFPR1
Function
Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.
Biological Process
Biological Process activation of adenylate cyclase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process adenylate cyclase-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process extracellular matrix organizationIEA:Ensembl
Biological Process hormone-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process lung connective tissue developmentIEA:Ensembl
Biological Process myofibroblast differentiationIEA:Ensembl
Biological Process nipple morphogenesisIEA:Ensembl
Biological Process parturitionIEA:Ensembl
Cellular Location
Cell membrane
Topology
Extracellular: 1-409
Helical: 410-430
Cytoplasmic: 431-443
Helical: 444-464
Extracellular: 465-486
Helical: 487-507
Cytoplasmic: 508-527
Helical: 528-548
Extracellular: 549-577
Helical: 578-598
Cytoplasmic: 599-629
Helical: 630-650
Extracellular: 651
Helical: 652-672
Cytoplasmic: 673-757
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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