Mouse Anti-LHCGR Recombinant Antibody (CBT2800) (V2LY-0625-LY254)

Name: Mouse Anti-LHCGR Recombinant Antibody (CBT2800)
SKU: V2LY-0625-LY254
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-LHCGR Recombinant Antibody (CBT2800) (V2LY-0625-LY254) in ELISA

Mouse Anti-LHCGR Recombinant Antibody (CBT2800) (V2LY-0625-LY254) in WB

Mouse Anti-LHCGR Recombinant Antibody (CBT2800) (V2LY-0625-LY254) in IF

Mouse Anti-LHCGR Recombinant Antibody (CBT2800) (V2LY-0625-LY254) in FC

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBT2800

Application

WB, ICC, FC

Immunogen

LHR-29 from ATCC

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
ICC	1:200-1:1,000
FC	1:200-1:400
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

lutropin-choriogonadotropic hormone receptor precursor

Entrez Gene ID

3973

UniProt ID

P22888

Function

Receptor for lutropin-choriogonadotropic hormone (PubMed:11847099).
The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11847099).

Biological Process

Activation of adenylate cyclase activityISS:BHF-UCL
Adenylate cyclase-activating G protein-coupled receptor signaling pathwayISS:BHF-UCL
Cellular response to gonadotropin stimulusISS:BHF-UCL
Cellular response to luteinizing hormone stimulusManual Assertion Based On ExperimentIMP:UniProtKB
CognitionManual Assertion Based On ExperimentIMP:UniProtKB
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerManual Assertion Based On ExperimentTAS:ProtInc
Hormone-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Luteinizing hormone signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Male genitalia developmentManual Assertion Based On ExperimentTAS:ProtInc
Male gonad developmentManual Assertion Based On ExperimentIBA:GO_Central
Ovarian follicle developmentManual Assertion Based On ExperimentIBA:GO_Central
Ovulation cycle processManual Assertion Based On ExperimentIBA:GO_Central
Phospholipase C-activating G protein-coupled receptor signaling pathwayISS:BHF-UCL
Positive regulation of inositol trisphosphate biosynthetic processISS:BHF-UCL

Cellular Location

Cell membrane

Involvement in disease

Familial male precocious puberty (FMPP):
In FMPP the receptor is constitutively activated.
Luteinizing hormone resistance (LHR):
An autosomal recessive disorder characterized by unresponsiveness to luteinizing hormone, defective sexual development in males, and defective follicular development and ovulation, amenorrhea and infertility in females. Two forms of the disorder have been defined in males. Type 1 is a severe form characterized by complete 46,XY male pseudohermaphroditism, low testosterone and high luteinizing hormone levels, total lack of responsiveness to luteinizing and chorionic gonadotropin hormones, lack of breast development, and absent development of secondary male sex characteristics. Type 2, a milder form, displays a broader range of phenotypic expression ranging from micropenis to severe hypospadias.

Topology

Extracellular: 27-363
Helical: 364-385
Cytoplasmic: 386-395
Helical: 396-416
Extracellular: 417-439
Helical: 440-462
Cytoplasmic: 463-482
Helical: 483-505
Extracellular: 506-525
Helical: 526-549
Cytoplasmic: 550-570
Helical: 571-594
Extracellular: 595-605
Helical: 606-627
Cytoplasmic: 628-699

PTM

Sulfated.

Xie, Y., Guo, W., Shen, X., Yu, W., Kuang, Y., Chen, Q., ... & Wang, L. (2023). A delayed ovulation of progestin-primed ovarian stimulation (PPOS) by downregulating the LHCGR/PGR pathway. Iscience, 26(8).

Makhdoomi, M. J., Shah, I. A., Rashid, R., Rashid, A., Singh, S., Shah, Z. A., & Ganie, M. A. (2023). Effect modification of LHCGR gene variant (rs2293275) on clinico-biochemical profile, and levels of luteinizing hormone in polycystic ovary syndrome patients. Biochemical Genetics, 1-15.

Alarcón-Granados, M. C., Moreno-Ortiz, H., Rondón-Lagos, M., Camargo-Villalba, G. E., & Forero-Castro, M. (2022). Study of LHCGR gene variants in a sample of colombian women with polycystic ovarian syndrome: A pilot study. Journal of King Saud University-Science, 34(6), 102202.

Singh, S., Kaur, M., Kaur, R., Beri, A., & Kaur, A. (2022). Association analysis of LHCGR variants and polycystic ovary syndrome in Punjab: a case–control approach. BMC Endocrine Disorders, 22(1), 335.

Flippo, C., Kolli, V., Andrew, M., Berger, S., Bhatti, T., Boyce, A. M., ... & Dauber, A. (2022). Precocious Puberty in a Boy With Bilateral Leydig Cell Tumors due to a Somatic Gain-of-Function LHCGR Variant. Journal of the Endocrine Society, 6(10), bvac127.

Widmer, S., Seefried, F. R., von Rohr, P., Häfliger, I. M., Spengeler, M., & Drögemüller, C. (2021). A major QTL at the LHCGR/FSHR locus for multiple birth in Holstein cattle. Genetics selection evolution, 53(1), 57.

Ga, R., Cheemakurthi, R., Kalagara, M., Prathigudupu, K., Balabomma, K. L., Mahapatro, P., ... & Muvvala, S. P. R. (2021). Effect of LHCGR gene polymorphism (rs2293275) on LH supplementation protocol outcomes in second IVF cycles: A retrospective study. Frontiers in Endocrinology, 12, 628169.

Wohlres-Viana, S., Arashiro, E. K. N., Minare, T. P., Fernandes, C. A. C., Grazia, J. G. V., Siqueira, L. G. B., ... & Viana, J. H. M. (2019). Differential expression of LHCGR and its isoforms is associated to the variability in superovulation responses of Gir cattle. Theriogenology, 126, 68-74.

Kawai, T., Richards, J. S., & Shimada, M. (2018). The cell type–specific expression of Lhcgr in mouse ovarian cells: evidence for a DNA-demethylation–dependent mechanism. Endocrinology, 159(5), 2062-2074.

Ponomarenko, I. V., Polonikov, A. V., & Churnosov, M. I. (2018). Polymorphic LHCGR gene loci associated with the development of uterine fibroids. Obstetrics and Gynecology, (10), 86-91.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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