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Mouse Anti-LHX3 Recombinant Antibody (2C10) (CBMAB-A4963-LY)

The product is antibody recognizes LHX3. The antibody 2C10 immunoassay techniques such as: WB, ELISA.
See all LHX3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2C10
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
LHX3 (NP_055379, 228 a.a. ~ 316 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
LHX3
Introduction
This gene encodes a member a large protein family which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required for pituitary development and motor neuron specification. Mutations in this gene have been associated with a syndrome of combined pituitary hormone deficiency and rigid cervical spine. Two transcripts variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq]
Entrez Gene ID
8022
UniProt ID
Q9UBR4
Alternative Names
DKFZp762A2013; LIM3; M2-LHX3
Function
Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity).
Required for the establishment of the specialized cells of the pituitary gland and the nervous system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1.
Biological Process
Animal organ morphogenesisManual Assertion Based On ExperimentTAS:ProtInc
Inner ear developmentManual Assertion Based On ExperimentIEP:UniProtKB
Lung developmentIEA:Ensembl
Medial motor column neuron differentiationIEA:Ensembl
Motor neuron axon guidanceIEA:Ensembl
Negative regulation of apoptotic processIEA:Ensembl
Neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Pituitary gland developmentIEA:Ensembl
Placenta developmentIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Positive regulation of transcription, DNA-templatedISS:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Spinal cord association neuron differentiationIEA:Ensembl
Spinal cord motor neuron cell fate specificationIEA:Ensembl
Ventral spinal cord interneuron specificationIEA:Ensembl
Cellular Location
Nucleus
Involvement in disease
Pituitary hormone deficiency, combined, 3 (CPHD3):
Combined pituitary hormone deficiency is defined as the impaired production of growth hormone and one or more of the other five anterior pituitary hormones. CPHD3 is characterized by a complete deficit in all but one (adrenocorticotropin) anterior pituitary hormone and a rigid cervical spine leading to limited head rotation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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