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Mouse Anti-LHX3 Recombinant Antibody (67.4E12) (CBMAB-0264-CN)

This product is a mouse antibody that recognizes LHX3 of mouse. The antibody 67.4E12 can be used for immunoassay techniques such as: ChIP, IF, IHC, WB.
See all LHX3 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Chicken, Human
Clone
67.4E12
Antibody Isotype
IgG1, κ
Application
ChIP, IF, IHC, WB

Basic Information

Immunogen
Full length cDNA/GST fusion
Specificity
Mouse, Chicken, Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
LHX3
Introduction
This gene encodes a member of a large family of proteins which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required for pituitary development and motor neuron specification. The protein is involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1.
Entrez Gene ID
Human8022
Mouse16871
Chicken373940
UniProt ID
HumanQ9UBR4
MouseP50481
ChickenP53412
Alternative Names
Lim3; P-LIM; mLIM3; mLim-3
Function
Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity).
Required for the establishment of the specialized cells of the pituitary gland and the nervous system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1.
Biological Process
Animal organ morphogenesisManual Assertion Based On ExperimentTAS:ProtInc
Inner ear developmentManual Assertion Based On ExperimentIEP:UniProtKB
Lung developmentIEA:Ensembl
Medial motor column neuron differentiationIEA:Ensembl
Motor neuron axon guidanceIEA:Ensembl
Negative regulation of apoptotic processIEA:Ensembl
Neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Pituitary gland developmentIEA:Ensembl
Placenta developmentIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Positive regulation of transcription, DNA-templatedISS:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Spinal cord association neuron differentiationIEA:Ensembl
Spinal cord motor neuron cell fate specificationIEA:Ensembl
Ventral spinal cord interneuron specificationIEA:Ensembl
Cellular Location
Nucleus
Involvement in disease
Pituitary hormone deficiency, combined, 3 (CPHD3):
Combined pituitary hormone deficiency is defined as the impaired production of growth hormone and one or more of the other five anterior pituitary hormones. CPHD3 is characterized by a complete deficit in all but one (adrenocorticotropin) anterior pituitary hormone and a rigid cervical spine leading to limited head rotation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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