Mouse Anti-LHX3 Recombinant Antibody (67.4E12) (CBMAB-0264-CN)

Name: Mouse Anti-LHX3 Recombinant Antibody (67.4E12)
SKU: CBMAB-0264-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

67.4E12

Application

ChIP, IF, IHC, WB

Immunogen

Full length cDNA/GST fusion

Specificity

Mouse, Chicken, Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

>95%, as determined by SDS-PAGE analysis

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

LHX3

Introduction

This gene encodes a member of a large family of proteins which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required for pituitary development and motor neuron specification. The protein is involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1.

Entrez Gene ID

Human	8022
Mouse	16871
Chicken	373940

UniProt ID

Human	Q9UBR4
Mouse	P50481
Chicken	P53412

Alternative Names

Lim3; P-LIM; mLIM3; mLim-3

Function

Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity).
Required for the establishment of the specialized cells of the pituitary gland and the nervous system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1.

Biological Process

Animal organ morphogenesisManual Assertion Based On ExperimentTAS:ProtInc
Inner ear developmentManual Assertion Based On ExperimentIEP:UniProtKB
Lung developmentIEA:Ensembl
Medial motor column neuron differentiationIEA:Ensembl
Motor neuron axon guidanceIEA:Ensembl
Negative regulation of apoptotic processIEA:Ensembl
Neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Pituitary gland developmentIEA:Ensembl
Placenta developmentIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Positive regulation of transcription, DNA-templatedISS:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Spinal cord association neuron differentiationIEA:Ensembl
Spinal cord motor neuron cell fate specificationIEA:Ensembl
Ventral spinal cord interneuron specificationIEA:Ensembl

Cellular Location

Nucleus

Involvement in disease

Pituitary hormone deficiency, combined, 3 (CPHD3):
Combined pituitary hormone deficiency is defined as the impaired production of growth hormone and one or more of the other five anterior pituitary hormones. CPHD3 is characterized by a complete deficit in all but one (adrenocorticotropin) anterior pituitary hormone and a rigid cervical spine leading to limited head rotation.

Singh, N., Singh, D., & Modi, D. (2022). LIM homeodomain (LIM-HD) genes and their co-regulators in developing reproductive system and disorders of sex development. Sexual Development, 16(2-3), 147-161.

Yasuoka, Y., & Taira, M. (2021). LIM homeodomain proteins and associated partners: Then and now. Current topics in developmental biology, 145, 113-166.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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