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Mouse Anti-LHX9 Recombinant Antibody (4C7) (CBMAB-A4984-LY)

The product is antibody recognizes LHX9. The antibody 4C7 immunoassay techniques such as: WB, ELISA.
See all LHX9 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4C7
Antibody Isotype
IgG2b, κ
Application
WB, ELISA

Basic Information

Immunogen
LHX9 (NP_001014434.1, 291 a.a. ~ 388 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
LIM homeobox 9
Introduction
This gene encodes a member of the LIM homeobox gene family of developmentally expressed transcription factors. The encoded protein contains a homeodomain and two cysteine-rich zinc-binding LIM domains involved in protein-protein interactions. The protein is highly similar to a mouse protein that causes gonadal agenesis when inactivated, suggesting a role in gonadal development. Alternative splicing results in multiple transcript variants. [provided by RefSeq]
Entrez Gene ID
56956
UniProt ID
Q9NQ69
Function
Involved in gonadal development.
Biological Process
Cell population proliferationIEA:Ensembl
Dorsal spinal cord interneuron anterior axon guidanceISS:UniProtKB
Female gonad developmentIEA:Ensembl
Gonad morphogenesisIEA:Ensembl
Male gonad developmentIEA:Ensembl
Negative regulation of transcription, DNA-templatedISS:UniProtKB
Neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus

Zhao, H., Jiang, R., Feng, Z., Wang, X., & Zhang, C. (2023). Transcription factor LHX9 (LIM Homeobox 9) enhances pyruvate kinase PKM2 activity to induce glycolytic metabolic reprogramming in cancer stem cells, promoting gastric cancer progression. Journal of Translational Medicine, 21(1), 833.

Singh, N., Singh, D., & Modi, D. (2022). LIM homeodomain (LIM-HD) genes and their co-regulators in developing reproductive system and disorders of sex development. Sexual Development, 16(2-3), 147-161.

Wheaton, B. J., Häggström, S. L., Muppavarapu, M., González‐Castrillón, L. M., & Wilson, S. I. (2022). Alternative LIM homeodomain splice variants are dynamically regulated at key developmental steps in vertebrates. Developmental Dynamics, 251(7), 1223-1243.

Gao, P., Sun, N., Zhao, T., Sun, Y., Gu, J., Ma, D., ... & Qi, X. (2022). Identification of prognostic indicators, diagnostic markers, and possible therapeutic targets among LIM homeobox transcription factors in breast cancer. Cancer Innovation, 1(3), 252-269.

Guo, R., Li, F., Lu, M., Ge, K., Gan, L., & Sheng, D. (2021). LIM Homeobox 9 knockdown by morpholino does not affect zebrafish retinal development. Biology Open, 10(3), bio056382.

Lu, C., Duan, C. C., & Bing, H. (2021). LIM Homeobox Transcription Factors as Novel Prognosis Biomarkers in Head and Neck Squamous Cell Carcinoma.

Song, L. (2020). The Role of Lhx9 in the Male Reproductive System (Doctoral dissertation, University of Otago).

Hu, F., Zhu, Q., Sun, B., Cui, C., Li, C., & Zhang, L. (2018). Smad ubiquitylation regulatory factor 1 promotes LIM‐homeobox gene 9 degradation and represses testosterone production in Leydig cells. The FASEB Journal, 32(9), 4627-4640.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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