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Mouse Anti-LILRA5 Recombinant Antibody (12K126) (CBMAB-L1548-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Leukocyte Immunoglobulin Like Receptor A5 (LILRA5). The antibody can be used for immunoassay techniques, such as FC.
See all LILRA5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
12K126
Antibody Isotype
IgG2a
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, 0.5% BSA
Preservative
0.1% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
LILRA5
Introduction
LILRA5 is a member of the leukocyte immunoglobulin-like receptor (LIR) family. LIR family members are known to have activating and inibitory functions in leukocytes. Crosslink of this receptor protein on the surface of monocytes has been shown to induce calcium flux and secretion of several proinflammatory cytokines, which suggests the roles of this protein in triggering innate immune responses. LILRA5 is one of the leukocyte receptor genes that form a gene cluster on the chromosomal region 19q13.4. Four alternatively spliced transcript variants encoding distinct isoforms have been described. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Osteoclast differentiation. An important paralog of this gene is LILRA6.LILRA5 may play a role in triggering innate immune responses. Does not seem to play a role for any class I MHC antigen recognition.
Entrez Gene ID
353514
UniProt ID
A6NI73
Alternative Names
CD85; LIR9; CD85F; ILT11; LIR-9; ILT-11; LILRB7
Function
May play a role in triggering innate immune responses. Does not seem to play a role for any class I MHC antigen recognition.
Biological Process
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Innate immune responseIEA:UniProtKB-KW
Negative regulation of interleukin-12 productionManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of interleukin-13 productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of calcium ion transportManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cell activationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of inflammatory responseManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of interleukin-1 beta productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of interleukin-10 productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of interleukin-6 productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of MAPK cascadeManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of protein tyrosine kinase activityManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cell membrane
Isoform 3:
Secreted
Topology
Extracellular: 42-268
Helical: 269-289
Cytoplasmic: 290-299
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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