LILRA5

LILRA5 is a member of the leukocyte immunoglobulin-like receptor (LIR) family. LIR family members are known to have activating and inibitory functions in leukocytes. Crosslink of this receptor protein on the surface of monocytes has been shown to induce calcium flux and secretion of several proinflammatory cytokines, which suggests the roles of this protein in triggering innate immune responses.

LILRA5

May play a role in triggering innate immune responses. Does not seem to play a role for any class I MHC antigen recognition.

Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Innate immune responseIEA:UniProtKB-KW
Negative regulation of interleukin-12 productionManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of interleukin-13 productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of calcium ion transportManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cell activationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of inflammatory responseManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of interleukin-1 beta productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of interleukin-10 productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of interleukin-6 productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of MAPK cascadeManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of protein tyrosine kinase activityManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIDA:UniProtKB

Cell membrane
Isoform 3:
Secreted

Extracellular: 42-268
Helical: 269-289
Cytoplasmic: 290-299