Mouse Anti-LILRB2 Recombinant Antibody (CBYY-I0052) (CBMAB-I0131-YY)

leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs).

ILT4; LIR2; CD85D; ILT-4; LIR-2; MIR10; MIR-10

Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed:11169396, PubMed:12853576, PubMed:16455647, PubMed:20448110, PubMed:27859042).
Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance (PubMed:20448110, PubMed:27859042, PubMed:16455647).
Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:11875462, PubMed:12853576, PubMed:9548455, PubMed:9842885).

Adaptive immune responseIEA:UniProtKB-KW
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Cellular defense responseManual Assertion Based On ExperimentTAS:ProtInc
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIMP:BHF-UCL
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Fc receptor mediated inhibitory signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Heterotypic cell-cell adhesionManual Assertion Based On ExperimentIDA:BHF-UCL
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Immune response-inhibiting cell surface receptor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Interleukin-10-mediated signaling pathwayManual Assertion Based On ExperimentIEP:ARUK-UCL
Learning or memoryBy SimilarityISS:ARUK-UCL
Negative regulation of antigen processing and presentationManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of calcium ion transportManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of postsynaptic density organizationIC:ARUK-UCL
Negative regulation of protein metabolic processBy SimilarityISS:ARUK-UCL
Negative regulation of T cell costimulationManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of T cell proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of interleukin-6 production1 PublicationNAS:BHF-UCL
Positive regulation of long-term synaptic depressionBy SimilarityISS:ARUK-UCL
Positive regulation of protein dephosphorylationBy SimilarityISS:ARUK-UCL
Positive regulation of regulatory T cell differentiationManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of T cell proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of T cell tolerance inductionManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of tolerance inductionManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of dendritic cell differentiation1 PublicationIC:BHF-UCL
Regulation of long-term synaptic potentiationBy SimilarityISS:ARUK-UCL
Signal transductionManual Assertion Based On ExperimentIDA:BHF-UCL

Cell membrane

Extracellular: 22-460
Helical: 461-481
Cytoplasmic: 482-597

Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6.