Mouse Anti-LILRB5 Recombinant Antibody (CBYJL-1698) (CBMAB-L1577-YJ)

Name: Mouse Anti-LILRB5 Recombinant Antibody (CBYJL-1698)
SKU: CBMAB-L1577-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYJL-1698

Application

Immunogen

Mouse myeloma cell line NS0-derived recombinant human LILRB5/CD85c/LIR-8 isoform 1, Arg18-His456, Accession # O75023.

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, Trehalose

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Leukocyte Immunoglobulin Like Receptor B5

Introduction

LILRB5 is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. LILRB5 belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Several other LIR subfamily B receptors are expressed on immune cells where they bind to MHC class I molecules on antigen-presenting cells and inhibit stimulation of an immune response. Multiple transcript variants encoding different isoforms have been found for this gene. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Osteoclast differentiation.

Entrez Gene ID

10990

UniProt ID

O75023

Alternative Names

LIR8; CD85C; LIR-8

Function

May act as receptor for class I MHC antigens.

Biological Process

Adaptive immune responseIEA:UniProtKB-KW
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Defense responseManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Membrane

Topology

Extracellular: 24-458
Helical: 459-479
Cytoplasmic: 480-590

Tornio, A., Bigossi, M., Siddiqui, M. K., Kennedy, G., Melhem, A., Chourasia, M. K., ... & Palmer, C. N. (2023). The cholesterol-lowering effect of statins is modified by LILRB5 intolerance genotype: Results from a recruit-by-genotype clinical trial. Frontiers in Pharmacology, 14, 1090010.

Taylor, A., Pola, R., Dawed, A. Y., Tornio, A., Palmer, C. N., & Siddiqui, M. K. (2022). Common Statin Intolerance Variants in ABCB1 and LILRB5 Show Synergistic Effects on Statin Response: An Observational Study Using Electronic Health Records. Pharmacogenomics of Adverse Drug Reactions (ADRs).

Melhem, A. L., Chourasia, M. K., Bigossi, M., Maroteau, C., Taylor, A., Pola, R., ... & Siddiqui, M. K. (2021). Common statin intolerance variants in ABCB1 and LILRB5 show synergistic effects on statin response: an observational study using electronic health records. Frontiers in Genetics, 12, 713181.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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